[phenixbb] The experiment is still very much needed (though AlphaFold helps a lot)

[Roberto Steiner]

Great paper indeed!

However quite significant progress seems to have been achieved with ligands (and not only)...https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/
Has anyone in the community put this to the test?


Best wishes
Roberto



Roberto A Steiner
www.steinerlab.org<http://www.steinerlab.org/>
https://twitter.com/steiner_lab

roberto.steiner at kcl.ac.uk<mailto:roberto.steiner at kcl.ac.uk>
Randall Centre for Cell and Molecular Biophysics
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Dipartimento di Scienze Biomediche
Università degli Studi di Padova
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On 30 Nov 2023, at 22:35, Tom Terwilliger <tterwilliger at newmexicoconsortium.org<mailto:tterwilliger at newmexicoconsortium.org>> wrote:

Hi Structural biologist colleagues!

Our article that helps you make the case that the experiment is still very much needed is now out:

https://www.nature.com/articles/s41592-023-02087-4

"AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination."  Nature Methods (2023)

Also, here is a video on the Phenix Tutorials YouTube channel that describes this analysis:  https://www.youtube.com/watch?v=ugMPYdPo8Bc

(I hope you will be happy to see that you and your structural biology colleagues get the credit for making AlphaFold possible at 2:35 in the introduction of this video!  Keep up the fantastic structural biology work!)

All the best,
Tom T
--
Thomas C Terwilliger
Laboratory Fellow, Los Alamos National Laboratory
Senior Scientist, New Mexico Consortium
100 Entrada Dr, Los Alamos, NM 87544
Email: tterwilliger at newmexicoconsortium.org<mailto:tterwilliger at newmexicoconsortium.org>
Tel: 505-431-0010


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