[phenixbb] Question about phenix.resolve_cryo_em

[Tom Terwilliger]

Hi Reza,

If you use a model in density modification with resolve_cryo_em, it is
necessary to create a multi-model ensemble with refinement in order to
reduce model bias. For details on why this works and is necessary, see:

https://scripts.iucr.org/cgi-bin/paper?S205979832001061X

All the best,
Tom T

On Fri, Nov 17, 2023 at 4:00 PM Reza Khayat <rkhayat at ccny.cuny.edu> wrote:

> ​Hi,
>
> Is it possible to turn off the model refinement procedure in
> phenix.resolve.cryo_em and go straight into density modification? My
> current model fits reasonably well. Also, Does the routine work well with
> nucleic acid (e.g. something like RNA from ribosome)?
>
> Best wishes,
> Reza
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-- 
Thomas C Terwilliger
Laboratory Fellow, Los Alamos National Laboratory
Senior Scientist, New Mexico Consortium
100 Entrada Dr, Los Alamos, NM 87544
Email: tterwilliger at newmexicoconsortium.org
Tel: 505-431-0010
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