<html><body><div style="color:#000; background-color:#fff; font-family:times new roman, new york, times, serif;font-size:12pt"><div><span>Dear All,</span></div><div><br><span></span></div><div><span>What it means if the Rwork or Rfree increase slightly during refinement?</span></div><div><br><span></span></div><div><span>Best regards.</span></div><div><br><span></span></div><div><span>Dialing</span></div><br> <div style="font-family: times new roman, new york, times, serif; font-size: 12pt;"><br> </div>  </div></body></html>