<div dir="ltr"><b style><span style="font-size:14pt;font-family:"Times New Roman","serif"">Macromolecular
Crystallography, Biophysics and Biochemistry</span></b>
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Two post-doctoral fellowship positions are available at the University of Texas
Medical Branch (UTMB) located in the greater Houston area in the research team
of Dr. Gabrielle Rudenko. We study molecules that mediate the formation,
maintenance and plasticity of synapses, the contact and communication point
between neurons. Our proteins of interest organize and regulate protein
interaction networks in the synaptic cleft and impact how neurons communicate
with each other at synapses. Many of the proteins we study are implicated in
neurological disease and serve as potential novel therapeutic targets.</span><b style><span style="font-size:14pt;font-family:"Times New Roman","serif""></span></b></p>
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<p class="MsoNormal" style="margin-bottom:0.0001pt;text-align:justify;line-height:normal"><span style="font-size:12pt;font-family:"Times New Roman","serif"">We are looking for highly motivated,
enthusiastic, hard working individuals who are interested in combining the
fields of structural biology and neuroscience. Research projects involve
protein over-expression and purification, x-ray crystallography, biochemical
and biophysical techniques, proteomics, chemical biology and in collaboration
electron microscopy and NMR.</span></p>
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<p class="MsoNormal" style="margin-bottom:0.0001pt;text-align:justify;line-height:normal"><span style="font-size:12pt;font-family:"Times New Roman","serif"">Our laboratory is joining the
endowed Sealy Center for Structural Biology and Molecular Biophysics and the
Department of Pharmacology/Toxicology at UTMB. The Sealy Center provides access
to exceptional facilities</span><span style="font-size:12pt;font-family:"Times New Roman","serif"">,
training and experimental assistance. <u>X-ray facilities</u> include a
high-brilliance FR-E<sup> </sup>Superbright x-ray generator, a Rigaku R-AXIS-IV
dual 30cm Imaging Plate detector, a Bruker SMART 2K CCD and a Rigaku
BioSAXS-1000 2D-Kratky camera (for solution scattering data). <u>Biophysics facilities</u>
include equipment for analytical ultracentrifugation, fluorescence, MALDI-TOF
mass spectrometry, dynamic light scattering, surface plasmon resonance,
titration micro-calorimetry, and high throughput screening with the ThermoFluor
HTS apparatus. In addition, the <u>Electron Microscopy facilities</u> house
three modern JEOL cryo-electron microscopes (a 200 keV JEOL 2200FS cryo-EM with
in-column electron energy filter and field emission gun, a 200 keV JEOL 2100
EM, and a 120 keV JEM1400 microscope) and the</span><span style="font-size:12pt;font-family:"Times New Roman","serif"">
</span><u><span style="font-size:12pt;font-family:"Times New Roman","serif"">NMR
facilities</span></u><span style="font-size:12pt;font-family:"Times New Roman","serif"">
include three NMR spectrometers (Bruker Avance III 800, 750 and 600 MHz with
cryoprobes).</span><span style="font-size:12pt;font-family:"Times New Roman","serif""> See </span><a href="http://www.scsb.utmb.edu/resources/"><span style="font-size:12pt;font-family:"Times New Roman","serif"">http://www.scsb.utmb.edu/resources/</span></a><span style="font-size:12pt;font-family:"Times New Roman","serif""></span></p>
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<p class="MsoNormal" style="margin-bottom:0.0001pt;text-align:justify;line-height:normal"><span style="font-size:12pt;font-family:"Times New Roman","serif"">UTMB
is part of the Texas Medical Center, the world�s largest medical center located
in greater Houston. UTMB is situated on Galveston Island offering a pleasant
subtropical climate and miles of relaxing beaches. UTMB is located within
commuting distance of Houston, the fourth largest city in the United States and
a leader in the arts, education, and health care.</span></p>
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<b style>Qualifications:</b> Applicants should
have received a Ph.D. degree in a field relevant to structural biology in the past three years and have a
strong publication record. Applicants with experience in cloning, bacterial/insect
cell culture, protein purification and crystallization, and macromolecular structure
determination are preferred. However, recent graduates with a strong background
in protein over-expression and purification, and an exceptional interest in
learning crystallography are also encouraged to apply. Good written and oral
communication skills in English are essential as well as the ability and desire
to work as part of a highly motivated, collaborative team.</span></p>
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To apply please e-mail the following to </span><a href="mailto:rudenkolab.application@gmail.com"><b style><span style="font-size:12pt;font-family:"Times New Roman","serif"">rudenkolab.application@gmail.com</span></b></a><span style="font-size:12pt;font-family:"Times New Roman","serif"">:� CV, contact information for three references
(address, phone and e-mail), a list of your experimental expertise and skills
relevant to this position, and a research statement describing your past
research experience and future goals (1-2 pages). Visa sponsorship is available
for non-US nationals. For questions please contact Dr. Gabrielle Rudenko at </span><a href="https://web.mail.umich.edu/blue/imp/message.php?mailbox=INBOX&index=111546"><span style="font-size:12pt;font-family:"Times New Roman","serif""></span></a><a href="mailto:rudenkolab.application@gmail.com"><b style><span style="font-size:12pt;font-family:"Times New Roman","serif"">rudenko@umich.edu</span></b></a><span style="font-size:12pt;font-family:"Times New Roman","serif"">.
</span></p>
<p class="MsoNormal" style="margin-bottom:0.0001pt;text-align:justify;line-height:normal"><span style="font-size:12pt;font-family:"Times New Roman","serif"">For more information please visit </span><a href="http://www.lsi.umich.edu/facultyresearch/labs/rudenko" target="_blank"><span style="font-size:12pt;font-family:"Times New Roman","serif"">http://www.lsi.umich.edu/facultyresearch/labs/rudenko</span></a><span style="font-size:12pt;font-family:"Times New Roman","serif"">. </span></p>
<p class="MsoNormal" style="margin-bottom:0.0001pt;text-align:justify;line-height:normal"><span style="font-size:12pt;font-family:"Times New Roman","serif"">The University of Texas is a
non-discriminatory, affirmative action employer.</span></p>
<br clear="all"><br>-- <br><br>Gabrielle Rudenko PhD<br>Life Sciences Institute and the Dept. of Pharmacology<br>University of Michigan Medical School<br>210 Washtenaw Ave Rm 3163A<br>Ann Arbor, Michigan 48109-2216<br>734 - 615 9323<br>
<br><a href="mailto:rudenko@umich.edu" target="_blank">rudenko@umich.edu</a><br><cite><a>www.lsi.umich.edu/facultyresearch/labs/</a>rudenko</cite><br>
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