<div dir="ltr">On Thu, Nov 7, 2013 at 10:44 AM, Zhihong Yu <span dir="ltr"><<a href="mailto:nkyuzhih@gmail.com" target="_blank">nkyuzhih@gmail.com</a>></span> wrote:<br><div class="gmail_extra"><div class="gmail_quote">
<blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr"><div class="gmail_extra"><div class="gmail_quote"><div>Thanks for your reply. So from your answer, I feel that maybe it's not worth to spend much time to resolve the structure through MR based on current dataset? Even I can correctly place the domainB, it's still hard to resolve the intact protein structure without other phasing information, is that right?</div>
</div></div></div></blockquote><div><br></div><div>There's no absolute rule, but it's extremely difficult even with higher resolution data. �Sometimes density modification would help but I suspect the phases just won't be good enough. �With an R-free of 0.55 it is very unlikely that you'll be able to see anything interpretable in the maps, even if the model placement is correct.</div>
<div><br></div><div>-Nat</div></div></div></div>