<div dir="ltr"><div class="gmail_default"><span style="color:rgb(34,34,34);font-size:12.8000001907349px">Dear colleagues,</span><br style="color:rgb(34,34,34);font-size:12.8000001907349px"><br style="color:rgb(34,34,34);font-size:12.8000001907349px"><span style="color:rgb(34,34,34);font-size:12.8000001907349px">We have an opening for a </span><span style="color:rgb(34,34,34)">Scientist-I (Structural Biology) </span><div class="gmail_default" style="display:inline"><font color="#000000"><span style="font-size:12.8000001907349px">position​</span></font></div><span style="color:rgb(34,34,34);font-size:12.8000001907349px"> here in Frederick, MD. If not interested, please forward this email to those who might be.  </span><br style="color:rgb(34,34,34);font-size:12.8000001907349px"><br style="color:rgb(34,34,34);font-size:12.8000001907349px"><span style="color:rgb(34,34,34);font-size:12.8000001907349px">To apply for this </span><div class="gmail_default" style="color:rgb(0,0,0);font-size:12.8000001907349px;display:inline">​position</div><span style="color:rgb(34,34,34);font-size:12.8000001907349px"> and for further details, including a job description and qualifications, please click on the link below:</span><div style="color:rgb(34,34,34);font-size:12.8000001907349px"><a href="http://jobs.leidos.com/ShowJob/Id/475028/Scientist-I-615658-%28NCI%29/" target="_blank">http://jobs.leidos.com/ShowJob/Id/475028/Scientist-I-615658-%28NCI%29/</a><br><br>Thank you<br>Dhirendra<div class="gmail_default"><br></div><div class="gmail_default"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit"><font face="arial, helvetica, sans-serif"><br></font></strong></div><div class="gmail_default"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit"><font face="arial, helvetica, sans-serif">------</font></strong></div><div class="gmail_default"><font face="arial, helvetica, sans-serif" style="color:rgb(0,0,0)"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit;line-height:17px;color:rgb(51,51,51)">JOB DESCRIPTION </strong><br style="color:rgb(51,51,51);line-height:17px"><span style="color:rgb(51,51,51);line-height:17px">The Scientist I will work in support of the FNL/NCI RAS Initiative. One of the major objectives of the RAS initiative at the Frederick National Lab for Cancer Research (FNLCR) is to conduct structural analysis of KRAS mutants and biologically relevant KRAS activator/effector complexes in support of drug discovery efforts. The Scientist I will be responsible for: 1) carrying out structural studies on KRAS-effector complexes through the entire protein crystallographic process, including construct design, protein purification, biochemical and biophysical characterization, crystallization, X-ray data collection, structure determination and analysis, 2) working closely with an integrated team of protein scientists in the Protein Expression Laboratory (PEL) at the FNLCR, 3) participating in experimental design and to independently conduct experiments in a priority-driven environment, 4) completing projects independently and as part of a team, and providing timely updates of the project progress to their supervisor both informally and by formal report writing, and 5) generating high-quality peer-reviewed publications. </span><span style="color:rgb(51,51,51);line-height:17px">Work may involve the use of potentially hazardous chemical, biological, or radiological materials or may be located in areas where such materials are used. May require the use of personal protective equipment and adherence to strict safety protocols. </span><br style="color:rgb(51,51,51);line-height:17px"><br style="color:rgb(51,51,51);line-height:17px"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit;line-height:17px;color:rgb(51,51,51)">Qualifications:</strong><br style="color:rgb(51,51,51);line-height:17px"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit;line-height:17px;color:rgb(51,51,51)">BASIC QUALIFICATIONS</strong><span style="color:rgb(51,51,51);line-height:17px"> </span><br style="color:rgb(51,51,51);line-height:17px"></font><ul style="color:rgb(51,51,51);margin:10px 0px;padding:0px 0px 0px 25px;border:0px;vertical-align:baseline;list-style-position:outside;font-stretch:inherit;line-height:17px"><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">PhD in structural biology, protein biochemistry, crystallography, or in a related discipline from an accredited college or university appropriate to biomedical research, or eight (8) years’ experience in lieu of degree</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Foreign degrees must be evaluated for U.S. Equivalency</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">In addition to the educational requirements the candidate will need proven ability in all aspects of protein crystallography from construct design through structure determination and interpretation</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Extensive experience in crystallization of protein-ligand and protein-protein complexes</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Experience collecting data at synchrotron beamline and solving ab initio structures</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Expertise in commonly used crystallography software packages</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Proficiency in protein biochemical and biophysical characterization</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Record of publications in peer-reviewed journals</font></li></ul><font face="arial, helvetica, sans-serif" style="color:rgb(0,0,0)"><strong style="margin:0px;padding:0px;border:0px;vertical-align:baseline;font-stretch:inherit;line-height:17px;color:rgb(51,51,51)">PREFERRED QUALIFICATIONS</strong><br style="color:rgb(51,51,51);line-height:17px"></font><ul style="color:rgb(51,51,51);margin:10px 0px;padding:0px 0px 0px 25px;border:0px;vertical-align:baseline;list-style-position:outside;font-stretch:inherit;line-height:17px"><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Relevant postdoctoral experience in a structural biology laboratory.</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Experience working with small GTPases, RAS-related activator/effector proteins, or membrane-associated complexes.</font></li><li style="margin:0px 0px 0px 15px;padding:0px;border:0px;font-weight:inherit;font-style:inherit;vertical-align:baseline;font-variant:inherit;font-stretch:inherit;line-height:inherit;list-style:disc outside"><font face="arial, helvetica, sans-serif">Knowledge of molecular dynamics simulations and protein-ligand docking.</font></li></ul><div><font color="#333333" face="arial, helvetica, sans-serif"><span style="line-height:17px"><b>To apply</b>, click here: </span></font><a href="http://jobs.leidos.com/ShowJob/Id/475028/Scientist-I-615658-%28NCI%29/" target="_blank">http://jobs.leidos.com/ShowJob/Id/475028/Scientist-I-615658-%28NCI%29/</a></div></div></div></div></div>