<html><head><meta http-equiv="Content-Type" content="text/html charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">A three-year postdoctoral position is available with the group of Roger Williams at the MRC Laboratory of Molecular Biology in Cambridge, UK. <div class=""><br class=""></div><div class="">The project, which is funded by Cancer Research UK is aimed at understanding structural mechanisms of regulation of the target of rapamycin complexes. Specifically to undertake research to investigate the structures and regulation of the mTORC1 complex assembled with its regulators on lysosomal membranes. The objective is to determine the structures of mTORC1 in complexes with its regulators and to understand how these complexes assemble on lysosomal membranes. Methods involved in the study include large scale mammalian cell culture, cryo-electron microscopy; X-ray crystallography; hydrogen-deuterium exchange mass spectrometry; biophysical measurements of assembly on membranes by confocal microscopy, flow cytometry and single-molecule fluorescence; and enzyme assays. </div><div class=""><br class=""></div><div class="">The candidate should have a Ph.D. degree or due to complete doctoral studies within 6 months of applying. It is essential that the candidate has an enthusiasm for structural biology. Experience with electron microscopy, X-ray crystallography, mass spectrometry or large scale eukaryotic expression systems would be desirable, but a motivated candidate could learn any or all of these.</div><div class=""><br class=""></div><div class="">The MRC Laboratory of Molecular Biology is one of the birthplaces of modern molecular biology and has amazing support for all aspects of structural biology.</div><div class=""><br class=""></div><div class="">For full details, see the MRC link<a href="https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/68-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-68/en-GB" class=""> https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/68-Postdoctoral-Scientist-PNAC-Dr-Roger-Williams-LMB-68/en-GB</a></div><div class=""> or contact Roger Williams: email <a href="mailto:rlw@mrc-lmb.cam.ac.uk" class="">rlw@mrc-lmb.cam.ac.uk</a> or phone: +44 1223 267094</div><div class=""><br class=""></div><br class=""><div apple-content-edited="true" class=""><div class="" style="orphans: 2; text-align: -webkit-auto; widows: 2; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div class="" style="text-align: -webkit-auto; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><span class="Apple-style-span" style="border-collapse: separate; text-align: -webkit-auto; border-spacing: 0px;"><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div class="">Dr. Roger Williams, FMedSci</div><div class=""><a href="mailto:rlw@mrc-lmb.cam.ac.uk" class="">rlw@mrc-lmb.cam.ac.uk</a></div><div class="">MRC Laboratory of Molecular Biology</div><div class="">Francis Crick Avenue</div><div class="">Cambridge Biomedical Campus</div><div class="">Cambridge CB2 0QH</div><div class="">UK</div><div class="">Phone: +44 1223 267094</div></div></span></div></span></div></div></div></body></html>