<div dir="ltr"><div class="markdown-here-wrapper" style=""><p style="margin:1.2em 0px!important">Dear Phenix experts,<br>our project involves crystals <strong>A</strong> and <strong>B</strong>, which are nearly isomorphous and of a protein’s complexes with two different small molecules, respectively. <strong>A</strong> diffracts better than <strong>B</strong>.<br>The r-free flag from <strong>A</strong> was “attached” to <strong>B</strong>‘s input reflections with the CCP4 <code style="font-size:0.85em;font-family:Consolas,Inconsolata,Courier,monospace;margin:0px 0.15em;padding:0px 0.3em;white-space:pre-wrap;border:1px solid rgb(234,234,234);border-radius:3px;display:inline;background-color:rgb(248,248,248)">cad</code> command and is still associated to <strong>B</strong>‘s slightly different cell dimensions. Would/should this be reason enough for <code style="font-size:0.85em;font-family:Consolas,Inconsolata,Courier,monospace;margin:0px 0.15em;padding:0px 0.3em;white-space:pre-wrap;border:1px solid rgb(234,234,234);border-radius:3px;display:inline;background-color:rgb(248,248,248)">refine</code> to throw an error? The error message suggests changing the <code style="font-size:0.85em;font-family:Consolas,Inconsolata,Courier,monospace;margin:0px 0.15em;padding:0px 0.3em;white-space:pre-wrap;border:1px solid rgb(234,234,234);border-radius:3px;display:inline;background-color:rgb(248,248,248)">refinement.input.symmetry_safety_check</code> setting. Can this setting be changed in the GUI?<br>Thank you.<br>Wolfram Tempel</p>
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