<html><head><meta http-equiv="Content-Type" content="text/html charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">Dear all,<div class=""><br class=""></div><div class="">I should perhaps offer sincere apologies for posting the crystallography boards with NMR news ;-). </div><div class=""><br class=""></div><div class="">However, I will not do that, as I sincerely hope you will see that in an era of integration of structural methods, such opportunities can offer the chance for excellent and exciting scientific endeavours.</div><div class=""><br class=""></div><div class="">iNEXT (<a href="http://www.inext-eu.org" class="">http://www.inext-eu.org</a>) is committed to bring structural methods closer to non-experts, by <b class=""><u class="">funding access</u> to world class infrastructures for Structural Biology</b>. Major tools for achieving that goal are the so-called <b class="">Extended Support modalities</b>. </div><div class=""><br class=""></div><div class="">We are happy to announce the start for acess to the iNEXT <b class="">Enhanced Support modality for NMR (NMR assignment, structure, dynamics). </b>In this mode, the NMR groups in Florence, Frankfurt and Utrecht are involved in guiding and training NMR novices. This iNEXT access modality also targets "new users with backgrounds other than Structural Biology”, so please feel free to forward that also to your biochemistry friends. Facility personnel will be involved to guide assignments, titrations, structure calculations, relaxation analyses, etc.</div><div class=""><br class=""></div><div class="">I also want to bring your attention to <b class="">a few more iNEXT news</b>:</div><div class=""><br class=""></div><div class="">- The <b class="">Structural Audit</b>, now allows multiple samples in a related project to be submitted in a single application for stability assessment and crystallisation screening; a basic analysis by SAXS, EM, or NMR is also supported (single click in application!) if an appropriate sample is available.</div><div class=""><br class=""></div><div class="">- The Enhanced Support modality "<b class="">From macromolecular sample to X-ray data collection</b>” is now better integrated with Structural Audit; applications can be combined, so in case of a successful Audit, you could rapidly proceed to further X-ray experiments (crystal optimisation, SAXS and/or crystallography)</div><div class=""><br class=""></div><div class="">- The Enhanced Support modality "<b class="">Advanced light imaging</b>” to support structural studies with in cells measurement of protein interaction kinetics, have also been made recently available.</div><div class=""><br class=""></div><div class="">- The Enhanced Support modality "<b class="">Cryo-EM sample optimisation</b>” for hands-on assistance in optimizing a sample for single particle EM is a great chance to move your sample towards cryo-EM!</div><div class=""><br class=""></div><div class="">- The Enhanced Support modality "<b class="">Macromolecular interactions</b>” is your chance for access to a Biophysics facility with various instruments and hands-on support for performing and analysing experiments to quantify a variety of interactions.</div><div class=""><br class=""></div><div class="">- All the High-End modalities (<b class="">X-rays, NMR, cryo-EM</b>) are always open for access!</div><div class=""><br class=""></div><div class="">So, please, <a href="https://www.structuralbiology.eu/update/submit-proposal?t=inext" class="">submit your proposal now!</a> … and keep in mind that a limited amount of the funding (~10%) can go towards projects that are not in an EU-country or associated country.</div><div class=""><br class=""></div><div class="">On behalf of the iNEXT Management,<br class=""><br class="">Best wishes,<br class=""></div><div class=""><br class=""></div><div class="">Tassos</div><div class=""><br class=""></div><div class=""><br class=""><div apple-content-edited="true" class="">
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px;"><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><span class="Apple-style-span" style="font-size: 12px; ">Anastassis (Tassos) Perrakis, Principal Investigator / Staff Member</span><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><div apple-content-edited="true" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; font-size: 12px; " class=""><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; " class=""><font face="Helvetica" size="3" style="font: normal normal normal 12px/normal Helvetica; " class="">Department of Biochemistry (B8)</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; " class=""><font face="Helvetica" size="3" style="font: normal normal normal 12px/normal Helvetica; " class="">Netherlands Cancer Institute, </font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; " class=""><font face="Helvetica" size="3" style="font: normal normal normal 12px/normal Helvetica; " class="">Dept. B8, 1066 CX Amsterdam, The Netherlands</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; " class=""><font face="Helvetica" size="3" style="font: normal normal normal 12px/normal Helvetica; " class="">Tel: +31 20 512 1951 Fax: +31 20 512 1954 Mobile / SMS: +31 6 28 597791</font></div><div class=""><br class=""></div></div></div></span><br class="Apple-interchange-newline"></span></span><br class="Apple-interchange-newline"></span></span><br class="Apple-interchange-newline">
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