<div dir="ltr">I have calculated Mathews coefficient also, the probability shows five molecules in ASU. But it fails to convince my supervisor.<br></div><div class="gmail_extra"><br><div class="gmail_quote">On Mon, Dec 12, 2016 at 6:52 AM, <span dir="ltr"><<a href="mailto:oleg@quantumbioinc.com" target="_blank">oleg@quantumbioinc.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Compute Matthews coefficient.<br>
e.g. using<br>
<a href="http://www.ruppweb.org/mattprob/default.html" rel="noreferrer" target="_blank">http://www.ruppweb.org/<wbr>mattprob/default.html</a><br>
<br>
Oleg<br>
<span class=""><br>
<br>
<br>
-----Original Message-----<br>
From: "Sharan Karade" <<a href="mailto:sharankarade@gmail.com">sharankarade@gmail.com</a>><br>
Sent: Sunday, December 11, 2016 6:05am<br>
To: <a href="mailto:phenixbb@phenix-online.org">phenixbb@phenix-online.org</a><br>
Subject: [phenixbb] Asymmetric unit content<br>
<br>
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</span>Unsubscribe: phenixbb-leave@phenix-online.<wbr>orgDear all,<br>
<div><div class="h5"><br>
I have solved the structure in C121 space group, having five<br>
molecules in asymmetric unit, my supervisor have doubt about the fifth<br>
molecule becoz of poor density fit, if i delete the fifth molecule, there<br>
is a space for the molecule and crystal is not continuous, i calculated<br>
difference map from Phenix by deleting fifth molecule and got the Map<br>
showing presence of molecule. My supervisor want me to get SetMet data, but<br>
crystals are diffracting poor (7A). Is there any way to convince my guide.<br>
<br>
<br>
advance thanks for valuable suggestions.<br>
<br>
--<br>
Sharan<br>
C/O Dr. J V Pratap<br>
Senior Research Fellow,<br>
CSIR-Central Drug Research Institute,<br>
Lucknow<br>
<br>
</div></div>Oleg Borbulevych, Ph.D.<br>
Staff Scientist<br>
QuantumBio, Inc.<br>
2790 W. College Ave.<br>
State College, PA 16801<br>
E-mail: <a href="mailto:oborbulevych@yahoo.com">oborbulevych@yahoo.com</a>, <a href="mailto:oleg@quantumbioinc.com">oleg@quantumbioinc.com</a><br>
Linkedin Professional Profile: <a href="http://www.linkedin.com/pub/oleg-borbulevych/22/454/b80" rel="noreferrer" target="_blank">http://www.linkedin.com/pub/<wbr>oleg-borbulevych/22/454/b80</a><br>
<br>
</blockquote></div><br><br clear="all"><br>-- <br><div class="gmail_signature" data-smartmail="gmail_signature">Sharan<br>C/O Dr. J V Pratap<br>Senior Research Fellow,<br>CSIR-Central Drug Research Institute,<br>Lucknow<br><br><br><br></div>
</div>