<html><head></head><body><div style="color:#000; background-color:#fff; font-family:HelveticaNeue, Helvetica Neue, Helvetica, Arial, Lucida Grande, Sans-Serif;font-size:16px"><div id="yui_3_16_0_ym19_1_1485359216377_14279">Dear All,</div><div id="yui_3_16_0_ym19_1_1485359216377_14279"><br></div><div id="yui_3_16_0_ym19_1_1485359216377_14279" dir="ltr">For the "refinement settings" in the phenix.refine graphical interface, will you please let me know when we need to change the parameters in "Refinement target weight..."? And is any rule on how to modify the parameters in "Refinement target weight..."?</div><div id="yui_3_16_0_ym19_1_1485359216377_14279" dir="ltr"><br></div><div id="yui_3_16_0_ym19_1_1485359216377_14279" dir="ltr">John</div></div></body></html>