<html><head><meta http-equiv="Content-Type" content="text/html charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">In July 2016, I finished a refinement with Phenix dev-2376 with these final stats<div class=""><font face="Courier" class=""> start final</font><br class=""><font face="Courier" class=""> ---------------------------------------</font><br class=""><font face="Courier" class=""> R-work: 0.1982 0.2007</font><br class=""><font face="Courier" class=""> R-free: 0.2376 0.2367</font><br class=""><font face="Courier" class=""> RMS(angles): 0.55 0.45</font><br class=""><font face="Courier" class=""> RMS(bonds): 0.003 0.002</font><br class=""><br class=""><br class="">Today, I reran the exact same parameter file and input files with Phenix dev-2712:</div><div class=""><br class=""></div><div class=""><div class=""><font face="Courier" class=""> start final</font></div><div class=""><font face="Courier" class=""> ---------------------------------------</font></div><div class=""><font face="Courier" class=""> R-work: 0.2073 0.2037</font></div><div class=""><font face="Courier" class=""> R-free: 0.2445 0.2442</font></div><div class=""><font face="Courier" class=""> RMS(angles): 0.55 0.45</font></div><div class=""><font face="Courier" class=""> RMS(bonds): 0.003 0.002</font></div><div class=""><font face="Courier" class=""><br class=""></font></div><div class=""><font face="Courier" class="">R-free values are now higher than they used to be.</font></div><div class=""><br class=""></div><div class="">This fact was also flagged when I ran Table 1 today.</div><div class=""><br class=""></div><div class="">-Mark</div><div class=""><br class=""></div><div class="">_______________________________________________</div><div class="">Mark A. Saper, Ph.D.<br class="">Associate Professor of Biological Chemistry, U-M Medical School<br class="">Room 3220B, MSRB III <a href="mailto:saper@umich.edu" class="">saper@umich.edu</a> +1 (734) 764-3353 </div><br class=""></div></body></html>