<div dir="ltr">Critical Assessment of Techniques for Protein Structure
Prediction (<span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span>) community
experiments aim to advance the state of the art in protein
structure modeling. Every other year since 1994, <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> collects information on
soon-to-be released experimental structures, passes on sequence
data to the structure modeling community, and collects blind
predictions of structure for assessment. About 100 modeling
groups from around the world participate. Results of <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> experiments are published in
special issues of the journal PROTEINS (e.g., CASP12: Proteins
Vol 86, Issue S1, March 2018).<br>
<br>
The thirteenth <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> round is
scheduled to start on <span class="gmail-aBn" tabindex="0"><span class="gmail-aQJ">May 1, 2018</span></span>. The organizing committee is
particularly keen to include many cryo-EM-derived structure
targets in this round.<br>
<br>
The success of <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> depends on
the generosity of the structure determination community.
Modeling targets are needed over a wide range of difficulty, for
modeling both with and without the aid of templates. Targets
that can be modeled based on structural templates should ideally
have 50% or less sequence identity to the templates. Access to
the structure in advance of its release by the PDB or its
publication is not needed. With sufficient notification to <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> (a minimum of three weeks before
release, more is better) there is no need to delay structure
release. If you have recently determined a novel protein
structure and will be depositing it to PDB, please suggest it as
a target for <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> by visiting <a href="http://www.predictioncenter.org/casp13/targets_submission.cgi" target="_blank">www.predictioncenter.org/casp1<wbr>3/targets_submission.cgi</a>.
If you have any questions please contact [log in to unmask]<br>
<br>
<span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> target providers are
regularly invited to contribute to special issue papers, for
example:<br>
<br>
2018: Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo
AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA,
Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS,
Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo
Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S,
Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S,
van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars
K, Zitzmann N, Schwede T. (2018). Target highlights from the
first post-PSI <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span> experiment
(CASP12, May-August 2016). Proteins 86 (S1), 27-50. doi:
10.1002/prot.25392. PMID: 2896053<br>
2016:
Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig
TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ,
Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad
J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ,
Singh AK, Wilson MA, Schwede T. (2016). Some of the most
interesting CASP11 targets through the eyes of their authors.
Proteins 84 (S1), 34-50. doi: 10.1002/prot.24942. PMID: 26473983<br>
2014: Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini
M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D,
Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson
DC, van Raaij MJ, Rohwer F, Segall A, Seguritan V, Zeth K,
Schwede T. (2014). Challenging the state-of-the-art in protein
structure prediction: Highlights of experimental target
structures for the 10th critical assessment of techniques for
protein structure prediction experiment CASP10. Proteins 82
(S2), 26-42. doi: 10.1002/prot.24489. PMID: 2431898<br>
2011: Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman
H, Casteel DE, Christodoulou E, Everett JK, Hausmann J,
Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J,
Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K,
Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ,
Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede
T. (2011). Target highlights in CASP9: Experimental target
structures for the critical assessment of techniques for protein
structure prediction. Proteins 79 (S10), 6-20. doi:
10.1002/prot.23196. PMID: 2202078<br>
<br>
Posted on behalf of the <span class="gmail-m_-5457273332579526165gmail-il"><span class="gmail-il">CASP</span></span>
organizing committee:<br>
John Moult, University of Maryland, USA<br>
Krzysztof Fidelis, University of California, Davis, USA<br>
Andriy Kryshtafovych, University of California, Davis USA<br>
Torsten Schwede, University of Basel, Switzerland<br></div>