<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69);" class="">Dear all,</div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69); min-height: 14px;" class=""> </div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69);" class="">By phenix.refine, I attempted to refine one molecule of protein.</div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69);" class="">R-free was improved in certain wxc by setting the weight wxu manually, however, the results of <span style="font-stretch: normal; line-height: normal; font-family: ".Hiragino Kaku Gothic Interface";" class="">“</span>Temp. fact. variance analysis<span style="font-stretch: normal; line-height: normal; font-family: ".Hiragino Kaku Gothic Interface";" class="">”</span> in <span style="font-stretch: normal; line-height: normal; font-family: ".Hiragino Kaku Gothic Interface";" class="">“</span>Validation<span style="font-stretch: normal; line-height: normal; font-family: ".Hiragino Kaku Gothic Interface";" class="">”</span> tool of COOT was worsened. </div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69);" class="">Why did such a thing happen?</div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69); min-height: 14px;" class=""><br class=""></div><div style="margin: 0px; font-stretch: normal; line-height: normal; font-family: "Helvetica Neue"; color: rgb(69, 69, 69);" class="">Thank you. </div><div class=""><br class=""></div><div class="">Manami</div><div class=""><br class=""></div><div class=""><br class=""></div>
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