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<p><tt>Postdoctoral position in structural biology of influenza
virus transcription Cusack group, EMBL Grenoble</tt></p>
<p> We are looking for a highly motivated and ambitious
individual to
<br>
progress our understanding of the mechanism of transcription by
<br>
influenza virus RNA-dependent RNA polymerase. The work is in the
frame
<br>
of the ANR-funded FluTranscript project that brings together the
<br>
complementary expertise of the groups of Stephen Cusack (EMBL
Grenoble,
<br>
project coordinator) and Nadia Naffakh (Institut Pasteur) in
structural
<br>
biology and molecular virology, respectively. The project follows
on
<br>
from a recent joint publication (Structural basis of an essential
<br>
interaction between influenza polymerase and Pol II CTD. Lukarska
et al,
<br>
Nature 2017) and aims to reconstitute and determine the structure
of
<br>
functional transcription complexes. A secondary goal is to use the
<br>
acquired structural information to develop new approaches to
<br>
anti-influenza drug development.
<br>
<br>
The Cusack group uses X-ray crystallography and cryo
<br>
electron-microscopy to study the structural biology of protein-RNA
<br>
complexes involved in RNA virus replication, innate immunity and
<br>
cellular RNA metabolism. Group website:
<br>
<a class="moz-txt-link-freetext"
href="https://www.embl.fr/research/unit/cusack/index.html">https://www.embl.fr/research/unit/cusack/index.html</a>
<br>
<br>
The successful candidate should have a PhD in Molecular
Biology or
<br>
related field and a strong background and interest in biochemistry
and
<br>
structural biology.
<br>
We are looking for a creative and ambitious person with good
<br>
communication skills and keen to work on a challenging project.
<br>
<br>
Experience in insect cell expression systems, reconstitution
of
<br>
protein-RNA complexes, X-ray crystallography or cryo-electron
microscopy
<br>
would be particularly beneficial.
<br>
<br>
EMBL is one of the world’s leading research organizations in
the
<br>
life sciences. The Headquarters Laboratory is located in
Heidelberg,
<br>
with additional sites in Barcelona, Grenoble, Hamburg, Hinxton,
and Rome.
<br>
<br>
EMBL Grenoble has excellent access to state-of-the-art
structural
<br>
biology technologies with the in house EM facility being equipped
with a
<br>
T12 microscope and 200kV Glacios/Falcon III . Additionally, we
have
<br>
access to the Titan Krios at the adjacent ESRF as well as those in
EMBL
<br>
Heidelberg. Other facilities on the Grenoble Campus include the
ESRF
<br>
synchrotron X-ray beamlines, neutron scattering at the ILL,
high-field
<br>
NMR at the IBS as well as high-throughput crystallization
platform,
<br>
mammalian and insect cell facilities, biophysical platform and
confocal
<br>
microscopy.
<br>
<br>
You can find out more about this vacancy at:
<br>
<a class="moz-txt-link-freetext"
href="https://www.embl.fr/jobs/searchjobs/index.php?ref=GR00133">https://www.embl.fr/jobs/searchjobs/index.php?ref=GR00133</a>
<br>
<br>
or by contacting Stephen Cusack: <a
class="moz-txt-link-abbreviated" href="mailto:cusack@embl.fr">cusack@embl.fr</a>
<br>
<br>
Please apply online through <a class="moz-txt-link-abbreviated"
href="http://www.embl.org/">www.embl.org/</a>
<br>
<br>
Stephen Cusack
<br>
</p>
<pre class="moz-signature" cols="72">--
**********************************************************************
Dr. Stephen Cusack, FRS
Head of Grenoble Outstation of the European Molecular Biology Laboratory (EMBL)
Group leader in structural biology of protein-RNA complexes and viral proteins
**********************************************************************
Email: <a class="moz-txt-link-abbreviated" href="mailto:cusack@embl.fr">cusack@embl.fr</a>
Website: <a class="moz-txt-link-freetext" href="http://www.embl.fr">http://www.embl.fr</a>
Tel: (33) 4 76 20 7238 Secretary (33) 4 76 20 7123
Fax: (33) 4 76 20 7199
Postal address: EMBL Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
Delivery address: EMBL Grenoble Outstation, Polygone Scientifique, 71 Avenue des Martyrs, 38000 Grenoble, France
**********************************************************************
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