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Dear all,
<p class="MsoNormal">This is a reminder that Diamond Light Source is accepting proposals for its XChem fragment screening facility, for the allocation period April to September 2020.<br>
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<p class="MsoNormal">The deadline is <b>Wednesday 2nd October at 5pm</b> (2 weeks from now).<br>
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<p class="MsoNormal">Details on how to apply are here - we're oversubscribed, so please follow the instructions!</p>
<p class="MsoNormal"> <a href="https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Applying-for-XChem.html">
https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Applying-for-XChem.html</a>
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<p class="MsoNormal">XChem is a platform for high-throughput crystal-based fragment screening, operational since 2015. We provide fragment libraries (or you can bring your own) and the pipeline entails: rapid crystal soaking with an Echo acoustic liquid handler;
high-throughput harvesting of hundreds of pre-soaked crystals using a Shifter; fully unattended data collection using dedicated beamtime on I04-1 beamline; and automated data integration along with tools for ligand detection (PanDDA) and streamlined model
building (XChemExplorer).<br>
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<p class="MsoNormal">Since April 2019, we offer both standard and Block Allocation Group (BAG) access. Standard access accommodates both Tier 1 and Tier 2 proposals, for exploratory and ready-to-go projects respectively.
<br>
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Since this summer, the FragLites library from Newcastle university (<i><span style="color:black;background:white">J. Med. Chem.</span></i><span style="color:black;background:white">20196273741-3752) is also available</span><span style="font-size:9.0pt;font-family:"Arial",sans-serif;color:black;background:white">
for users.</span>
<p class="MsoNormal">More information is on the XChem website: <br>
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<blockquote>
<p class="MsoNormal"><a moz-do-not-send="true" href="https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Methods-for-Fragment-Screening.html">https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening</a></p>
<p class="MsoNormal"><a moz-do-not-send="true" href="https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Fragment-Libraries.html">https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Methods-for-Fragment-Screening.html</a></p>
<p class="MsoNormal"><a moz-do-not-send="true" href="https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Fragment-Libraries.html">https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening/Fragment-Libraries.html</a></p>
</blockquote>
<p class="MsoNormal">For more questions, please ask Alice (copied) or myself. <br>
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We are looking forward to collaborating with you!
<p class="MsoNormal">The XChem team.</p>
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