<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
        {font-family:"Cambria Math";
        panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
        {font-family:Calibri;
        panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
        {margin:0cm;
        margin-bottom:.0001pt;
        font-size:11.0pt;
        font-family:"Calibri",sans-serif;
        mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
        {mso-style-priority:99;
        color:#0563C1;
        text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
        {mso-style-priority:99;
        color:#954F72;
        text-decoration:underline;}
p.msonormal0, li.msonormal0, div.msonormal0
        {mso-style-name:msonormal;
        mso-margin-top-alt:auto;
        margin-right:0cm;
        mso-margin-bottom-alt:auto;
        margin-left:0cm;
        font-size:11.0pt;
        font-family:"Calibri",sans-serif;}
span.EmailStyle18
        {mso-style-type:personal;
        font-family:"Calibri",sans-serif;
        color:windowtext;}
span.EmailStyle19
        {mso-style-type:personal;
        font-family:"Calibri",sans-serif;
        color:windowtext;}
span.EmailStyle20
        {mso-style-type:personal;
        font-family:"Calibri",sans-serif;
        color:windowtext;}
span.EmailStyle22
        {mso-style-type:personal;
        font-family:"Calibri",sans-serif;
        color:windowtext;}
span.EmailStyle23
        {mso-style-type:personal-compose;
        font-family:"Calibri",sans-serif;
        color:windowtext;}
.MsoChpDefault
        {mso-style-type:export-only;
        font-size:10.0pt;}
@page WordSection1
        {size:612.0pt 792.0pt;
        margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
        {page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-GB" link="#0563C1" vlink="#954F72">
<div class="WordSection1">
<p class="MsoNormal"><span style="color:black">Dear all, </span><span style="color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:black"><o:p>&nbsp;</o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white"><span style="color:black">As part of Diamond&#8217;s effort&nbsp;to combat&nbsp;COVID-19, we are offering fragment screening&nbsp;expertise and infrastructure to users working on COVID-19 related targets (as demonstrated
 by the recent&nbsp;<a href="https://www.diamond.ac.uk/covid-19/for-scientists/Main-protease-structure-and-XChem.html"><span style="color:#663399;border:none windowtext 1.0pt;padding:0cm">fragment screening campaign against SAR-CoV-2 Main protease</span></a>).<o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white"><span style="color:black"><o:p>&nbsp;</o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="color:black;background:white">In order to submit a proposal for COVID-19 related research please complete the&nbsp;</span><span style="color:black"><a href="https://fs3.formsite.com/DiamondLightSource/nynlkya9ks/index.html"><span style="color:#663399;border:none windowtext 1.0pt;padding:0cm;background:white">Rapid
 Access Form</span></a><span style="background:white">&nbsp;and send a completed&nbsp;</span><a href="https://www.diamond.ac.uk/dam/jcr:690e7c9d-7b4c-4a7d-bc58-9101e9af4df8/XChem%20Proposal%20-%20Oct2019.docx"><span style="color:#663399;border:none windowtext 1.0pt;padding:0cm;background:white">XChem
 Application Form</span></a><span style="background:white"> to </span><a href="mailto:covid19access@diamond.ac.uk">covid19access@diamond.ac.uk</a>.<o:p></o:p></span></b></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<span style="color:black">Due to access and travel restrictions, experienced XChem&nbsp;staff&nbsp;will&nbsp;prepare samples on-site, organise unattended data collection and analyse the data using the XCE pipeline.&nbsp;All data will then be made available&nbsp;to the users and&nbsp;as
 open access through&nbsp;<a href="https://fragalysis.diamond.ac.uk/viewer/react/landing">Fragalysis&nbsp;</a>and the Diamond webpage.<b><o:p></o:p></b></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<span style="color:black">Further details regarding crystal system requirements, available fragment libraries and screening protocols can be found
<a href="https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html">here</a>.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<span style="color:black">Kind regards, Daren<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Dr Daren Fearon<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">XChem Beamline Scientist<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Diamond Light Source Ltd<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Harwell Science &amp; Innovation Campus<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Didcot&nbsp; Oxfordshire&nbsp; OX11 0DE<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><o:p>&nbsp;</o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Tel:&nbsp; 01235 778936<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Email: <a href="mailto:daren.fearon@diamond.ac.uk">
<span style="color:blue">daren.fearon@diamond.ac.uk</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB">Web:<span style="color:black">
<a href="http://www.diamond.ac.uk/"><span style="color:blue">www.diamond.ac.uk</span></a><o:p></o:p></span></span></p>
<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
</div>
<p align="justify">&nbsp;</p>
<p align="justify">--&nbsp;</p>
<p align="justify">This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail.<br />Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. <br />Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message.<br />Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom<br />&nbsp;</p></body>
</html>