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<b><span style="font-size:14.0pt;font-family:"Arial",sans-serif">Postdoctoral position in cryo-EM and translation regulation ‒ from bacteria to neurons</span></b></p>
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<b><span style="font-size:14.0pt;font-family:"Arial",sans-serif">Korostelev Lab, University of Massachusetts Medical School</span></b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">We study how the ribosome interacts with numerous cellular components to achieve high accuracy and efficiency of gene expression. We’d like to understand the key roles of translation and ribosomes
in: (1) Neurodevelopment and neurodegenerative diseases; (2) Bacterial stress signaling and gene regulation (<i>e.g.</i> coupling with transcription); and other aspects of gene expression (</span><a href="https://www.umassmed.edu/korostelev-lab/" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">https://www.umassmed.edu/korostelev-lab/</span></a>)<span style="font-size:12.0pt;font-family:"Arial",sans-serif">.
We use a range of approaches, including cryo-EM and biochemistry (see selected references below).</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and highly interactive research community:
</span><a href="https://www.umassmed.edu/rti/about-the-rti/faculty-members/" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">https://www.umassmed.edu/rti/about-the-rti/faculty-members/</span></a><span style="font-size:12.0pt;font-family:"Arial",sans-serif">.
Our colleagues are interested in nearly all aspects of RNA biology, from small to large RNAs to RNA chemistry and therapeutics development.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">We seek a highly motivated person who very recently received a PhD, or will soon receive a PhD. Applications sent prior to the dissertation defense date are welcome.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">If you are interested in using single-particle cryo-EM and in
<i>situ </i>(cellular) EM to elucidate cellular mechanisms, <b>submit the following information to
</b></span><a href="mailto:ann.powers@umassmed.edu" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable"><b><i><span style="font-size:12.0pt;font-family:"Arial",sans-serif">ann.powers@umassmed.edu</span></i></b></a><span class="x_MsoHyperlink"><i><span style="font-size:12.0pt;font-family:"Arial",sans-serif">:</span></i></span><i><span style="font-size:12.0pt;font-family:"Arial",sans-serif"></span></i></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">1) <i>Your CV </i>
(including your publication list);<br>
2) <i>Cover letter</i> (less than 2 pages) describing: </span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif"> (i) your previous work - focusing on your most interesting finding(s),</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
<p class="x_MsoNormal" style="margin-right:58.5pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:140%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif"> (ii) your scientific interests,
</span></p>
<p class="x_MsoNormal" style="margin-right:171.35pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:140%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif"> (iii) which aspects of translation regulation are of interest to you.</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">3) <i>Email addresses of</i>
<i>three references</i>.</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></p>
<p class="x_MsoNormal" style="margin-right:171.05pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:120%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span></p>
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<b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Selected publications (accessible via the provided links):</span></b><b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"></span></b></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41467-020-19370-z&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048319137%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=3h1xTVVhDutkCMiVWyFwLup5IzVlHzNwJPifARLl0L4%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://www.nature.com/articles/s41467-020-19370-z" shash="kviqcrFlkcW5f9gOQlTIRTPSJqJVaZDzrPIWkodNoGmNJEuKo4riW2Cp4DHqslyrOguwgYUEcQXfWPRbyOatc3b7Q1nao8BA8BU2juvkdj80BFHPZm64SDlbkDtcDAgS6meg2S2y9iE/Sj2TQzU7r/l1tnXSOAdfuHTTzqdRy1Y=" title="Original URL: https://www.nature.com/articles/s41467-020-19370-z. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">ArfB
can displace mRNA to rescue stalled ribosomes</span></a><span style="font-family:"Arial",sans-serif">”.
<i>Nature Commun</i>. 2020.</span></p>
<p class="x_MsoNormal" style="margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:120%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Loveland AB, Demo G, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-020-2447-x&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048319137%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=OwJ9MZRWpN4ZQofCsUXlD1%2Bm3dJZdg8Kj736iJ0xVUA%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://www.nature.com/articles/s41586-020-2447-x" shash="D78pMELlE1SSxx5sOl2LmpkgH+9Lnbe+VGbinJ0gC1+std5DGLlvPSe/ILILx27d5QAVpwc7vyiECIfgQF2C+sf6iPS6ucm6YXMPUQzpp85GHbIJrZQbiiUz1wt5aTDByeFepx9H3cVN/j7NV7JAYaBqj1RzRFGxmTQwcIRcPAA=" title="Original URL: https://www.nature.com/articles/s41586-020-2447-x. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Cryo-EM
of elongating ribosome with EF-Tu GTP elucidates tRNA proofreading</span></a><span style="font-family:"Arial",sans-serif">”.
<i>Nature</i>. 2020.</span></p>
<p class="x_MsoNormal" style="margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:120%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, Korostelev AA. “</span><a href="file:///C:/Users/PowersA/Dropbox%20(UMass%20Medical%20School)/Korostelev/Job%20Postings/Susorov%20D%20et%20al.%20%22Termi-Luc:%20a%20versatile%20assay%20to%20monitor%20full-protein%20release%20from%20ribosomes" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable"><span style="font-family:"Arial",sans-serif">Ribosome
inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM</span></a><span style="font-family:"Arial",sans-serif">”.
<i>bioRxiv.</i> 2020.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Susorov D, Egri S, Korostelev AA. "</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Frnajournal.cshlp.org%2Fcontent%2Fearly%2F2020%2F08%2F14%2Frna.076588.120.abstract&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048329132%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=NI6Q8kXCtjc84z4aVgEGEsQOEoG08wCRMUqQl1m9sjA%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://rnajournal.cshlp.org/content/early/2020/08/14/rna.076588.120.abstract" shash="Jrfd9U6X8SFTmF0h6kRL6N2TzQWXZBgQh4BgvgilvkgWfHC8THmkqkDn6FcNSXuUDCDFhrJP5J2LXw017gBXKhE9U0pW7PUJWUt/NgQZ65OXimmZN3DlXEGVauASYsx1EkxqgjFnbW1fTOHpWYPxv9xiulIjFnW9lSfsbwsvOXM=" title="Original URL: https://rnajournal.cshlp.org/content/early/2020/08/14/rna.076588.120.abstract. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Termi-Luc:
a versatile assay to monitor full-protein release from ribosomes</span></a><span style="font-family:"Arial",sans-serif">”.
<i>RNA</i>. 2020.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Felifesciences.org%2Farticles%2F46850&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048329132%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=LPp6orK3diN10%2BeFTWzlVmPeXj%2FoHrh3t239XdVvfmk%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://elifesciences.org/articles/46850" shash="E+tRVxorKLiRbx4oKQbqYY4r52oBXUyDJRzHGC0TAiQLiAv6rX5hkIbo9hCt+EliH1igZKpcfdci29oGHNHaCqmb8C1cDet1OV+mCinOMAoO5/EaXnp9ow6ifEL7Ll4qqCbgDeOF/iONiPvz5jcgB9bp/n+/vcQ7v+f3eUJbRQg=" title="Original URL: https://elifesciences.org/articles/46850. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Extensive
ribosome and RF2 rearrangements during translation termination</span></a><span style="font-family:"Arial",sans-serif">”.
<i>eLife.</i> 2019.</span></p>
<p class="x_MsoNormal" style="margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:120%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Loveland AB, Demo G, Grigorieff N, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=http%3A%2F%2Fem.rdcu.be%2Fwf%2Fclick%3Fupn%3DKP7O1RED-2BlD0F9LDqGVeSIKXTPnBku1A9OWTgBG4xjQ-3D_rJ0Q-2F8zH14bc-2FDhyIYgAaaIoDtN-2BMVA8uQ8ik0weaaWU8PS-2BLdbyuwTFcQze4H7H3NsgdQgtZP22s4d-2F7Ah5F9SEpNUyeYFo-2BwrMeGTv8bX708iwdYFE7myt3Zo8qQ0eqg1fJusX-2BXV1bNBbSZvYswm3izFmUn2nSTQNeuX5exHYwsMvNwwmnHT-2F6JYMZF6tiuin7sd3OMFe1MjOiM4u2ETfX1BuxYea4ybObPoymQQ-3D&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048339128%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=r7bwGDNHCxLlCJ1tRaM3zmCa1LRTxG5Fk8gEaSSbhiU%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="http://em.rdcu.be/wf/click?upn=KP7O1RED-2BlD0F9LDqGVeSIKXTPnBku1A9OWTgBG4xjQ-3D_rJ0Q-2F8zH14bc-2FDhyIYgAaaIoDtN-2BMVA8uQ8ik0weaaWU8PS-2BLdbyuwTFcQze4H7H3NsgdQgtZP22s4d-2F7Ah5F9SEpNUyeYFo-2BwrMeGTv8bX708iwdYFE7myt3Zo8qQ0eqg1fJusX-2BXV1bNBbSZvYswm3izFmUn2nSTQNeuX5exHYwsMvNwwmnHT-2F6JYMZF6tiuin7sd3OMFe1MjOiM4u2ETfX1BuxYea4ybObPoymQQ-3D" shash="kxUTj2IN2RN7rP0NghPxPyo2ciiT0mY4etsipMN/j83VTvLwpId95OgN1tVv3fu8Wz+PFSNMWG0CnaOg553juFua+WuRXIqoun25UKSwnIa/fwgjQi9CfJACYsnLXaxxzJ5+gAjmaIy3KHJLUWunpid6E9cc822/ijVXEMECVKE=" title="Original URL: http://em.rdcu.be/wf/click?upn=KP7O1RED-2BlD0F9LDqGVeSIKXTPnBku1A9OWTgBG4xjQ-3D_rJ0Q-2F8zH14bc-2FDhyIYgAaaIoDtN-2BMVA8uQ8ik0weaaWU8PS-2BLdbyuwTFcQze4H7H3NsgdQgtZP22s4d-2F7Ah5F9SEpNUyeYFo-2BwrMeGTv8bX708iwdYFE7myt3Zo8qQ0eqg1fJusX-2BXV1bNBbSZvYswm3izFmUn2nSTQNeuX5exHYwsMvNwwmnHT-2F6JYMZF6tiuin7sd3OMFe1MjOiM4u2ETfX1BuxYea4ybObPoymQQ-3D. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Ensemble
cryo-EM elucidates the mechanism of translation fidelity</span></a><span style="font-family:"Arial",sans-serif">”.
<i>Nature</i>. 2017.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Felifesciences.org%2Farticles%2F28560&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048339128%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=3LZ0TgqtAe%2BqXUq%2FSqL1rSww%2Bw4sfDttOS1sWuewSvU%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://elifesciences.org/articles/28560" shash="mTxnCMkwBf8cDFc9YHcswcgmVx5gh8ql/R6Yu3NPfNucZ/j34tbSPyLV47wHXM3npJsa513BW3hUfmIFXTJpPjxoET/nDoTskOwASdLIXFGYABGF5qUFP+/RgTqHXQ4XMsjp0+lU2z6639Ua8Uz9rr5u3WbxuxgvictfuBZ8Zec=" title="Original URL: https://elifesciences.org/articles/28560. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Structure
of RNA polymerase bound to ribosomal 30S subunit</span></a><span style="font-family:"Arial",sans-serif">”.
<i>eLife</i>. 2017.</span></p>
<p class="x_MsoNormal" style="margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt;line-height:120%">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4896748%2F&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048349116%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=12IYwZEXPIVVGJx4PJFKq4PoNUa0Pze%2BKgi8JIE8KhQ%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896748/" shash="YiZZw3YwJ4oh/eFeK26VvHsgTyUw5F/a1oZia1xUY9JjqQP0sm7YXK6oYTf3iXtaaa/fGh7gcUimH95JfBpiEkkxGGMjqP+ZfcI2XjIl9hETtlaOjm789kCYZk1uROnT5tUZgzhWhj8MLgehCmm88SHg5N5PNzRkQzH1GQkEX6A=" title="Original URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896748/. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Ensemble
cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome</span></a><span style="font-family:"Arial",sans-serif">”.
<i>eLife</i>. 2016.</span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">• </span><span style="font-family:"Arial",sans-serif">Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. “</span><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Felifesciences.org%2Farticles%2F17029&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048349116%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=gKYMi0V8%2ByFj1C7Rv7PFK26N%2FvwsPfVjeqLYVDnwxW4%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://elifesciences.org/articles/17029" shash="iiHTF5X26Lytqj2IJIpJkkSKqLgsXzMbjVgzs41yyOE03X45fuDgidF8RvqJ0Z6a31h89sMevUhv8QkAz/LCxdfQyPXVwvr7LDc0+WxTP0lFq4UeLBAWpi5X129VTMuHIdOUCZwova2qwqPaCUdBw25b3dhwHOVEdCBy56xwbrs=" title="Original URL: https://elifesciences.org/articles/17029. Click or tap if you trust this link."><span style="font-family:"Arial",sans-serif">Ribosome•RelA
structures reveal the mechanism of stringent response activation</span></a><span style="font-family:"Arial",sans-serif">”.
<i>eLife</i>. 2016.</span></p>
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<p class="x_MsoNormal"><a href="https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftwitter.com%2Fkorostelevlab&data=04%7C01%7CAnna.Loveland%40umassmed.edu%7Ce628d89d1f79409b644108d88804e705%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C637408902048359112%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=kc3cSbAmCx2YDw7jcCAXehOznVbKfibSscFxR3B0UNg%3D&reserved=0" target="_blank" rel="noopener noreferrer" data-auth="Verified" originalsrc="https://twitter.com/korostelevlab" shash="Re7gO2vewK+MhGlJ7NuISWJj7+pvnjaowwSCA7KzVHjceuEeutkbyKhpvXfZVwdBdzQC6X9fma3M4GKNIMFNN5FUg0y/7W8RHQdkU73i7uCj1zpUnHabVD+GFpjZudmJU4RT6VZaDF5fAFMNrpvvTIDSg2Ps4OTq74xLHyrVTwc=" title="Original URL: https://twitter.com/korostelevlab. Click or tap if you trust this link."><span style="font-size:12.0pt;font-family:"Arial",sans-serif">https://twitter.com/korostelevlab</span></a></p>
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Anna Loveland, Ph.D.<br>
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617 610 4321 (cell)<br>
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