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<div style="margin:0px;font-size:12pt;color:black">Dear all, </div>
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<div style="margin:0px;font-size:12pt;color:black">(Apologies for the slightly off-topic cross-post - hopefully, this will be of interest to all MX practitioners, not just Diamond light source users.)</div>
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<div style="margin:0px;font-size:12pt;color:black">As Diamond User Committee MX representatives, we'd just like to remind you that the deadline for letters of support for Diamond-II beamline upgrades is this<span> </span><b>Friday, 20th November</b>.</div>
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<div style="margin:0px;font-size:12pt;color:black">As you are perhaps aware, the Diamond machine is scheduled for a major upgrade to a 4th generation source 2025-2027.</div>
<div style="margin:0px;font-size:12pt;color:black">Further information about the upgrade can be found<span> </span><a href="https://www.diamond.ac.uk/Home/About/Vision/Diamond-II.html" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://www.diamond.ac.uk/Home/About/Vision/Diamond-II.html" style="margin:0px">here</a>.</div>
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<div style="margin:0px;font-size:12pt;color:black">All MX beamlines will benefit from a brighter, more focused source � however, two MX beamlines have been selected as flagship projects for significant upgrades. </div>
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<div style="margin:0px;font-size:12pt;color:black"><b>I04-1 > K04 Ultra XChem.</b></div>
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The I04-1 fixed wavelength beamline used for the XChem fragment screening will be completely rebuilt as K04. </div>
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Briefly, K04 will allow higher throughput fragment screening (meaning more projects and more fragments can be screened) and it is hoped the improved characteristics of the Diamond-II beam will allow XChem methodologies to be extended to more difficult targets
such as transmembrane proteins. </div>
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The K04 proposal outline can be found<span> </span><a href="https://www.diamond.ac.uk/dam/jcr:bd879384-900b-4a2c-897d-a8e0e818c6e8/MX%20-%20I04-1%20XChem%20reinvention%20as%20K04%20XChem.pdf" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://www.diamond.ac.uk/dam/jcr:bd879384-900b-4a2c-897d-a8e0e818c6e8/MX%20-%20I04-1%20XChem%20reinvention%20as%20K04%20XChem.pdf" style="margin:0px">here</a> [PDF].</div>
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<b>I24 > KMX Kinetic micro crystallography.</b></div>
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The I24 microfocus beamline will be upgraded to enhance the capabilities of I24 and allowing analysis of smaller crystals, radiation-sensitive crystals, and expanding the serial synchrotron crystallography (SSX) functionality of the beamline. The abilities
to conduct room temperature SSX will also be enhanced to allow in-crystal kinetic analysis, with various on-line spectroscopic (Raman, UV-Vis, XES) detectors built into the end station.</div>
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The KMX proposal outline can be found<span> </span><a href="https://www.diamond.ac.uk/dam/jcr:add3277b-5bc2-4e8b-93a2-25d1e0e585f6/MX%20-%20I24%20KMX:%20kinetics%20and%20microfocus%20upgrade.pdf" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://www.diamond.ac.uk/dam/jcr:add3277b-5bc2-4e8b-93a2-25d1e0e585f6/MX%20-%20I24%20KMX:%20kinetics%20and%20microfocus%20upgrade.pdf" style="margin:0px">here</a><span> </span>[PDF] </div>
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Having read these proposals you will<span> </span><i>obviously</i><span> </span>be very excited by the possibilities and will want to submit your letters of support for both of them, by
<b>Friday, 20th November</b></div>
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<b>Letters of support can be submitted via this<span> </span><a href="https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u%C2%A0" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" title="https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u%C2%A0" style="margin:0px">link</a>. </b></div>
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Thanks in advance, </div>
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Dave & Arnaud. </div>
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<span style="color: rgb(0, 0, 0); font-family: Calibri, Helvetica, sans-serif; font-size: 12pt;">--</span><br>
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<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0"><b>Dr David C. Briggs</b></p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">Senior Laboratory Research Scientist</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">Signalling and Structural Biology Lab</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">The Francis Crick Institute</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">London, UK</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">==</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">Diamond User Committee MX representative</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">==</p>
<p style="margin-top:0px; margin-bottom:0px; margin-top:0; margin-bottom:0">about.me/david_briggs</p>
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<p style="color:rgb(112,113,115);font-family: 'Trebuchet MS', 'Lucida Grande'; font-style: italic; font-size: 10pt;">
The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT</p>
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