<div dir="ltr"><div><span style="color:rgb(51,51,51);font-family:Roboto,&quot;Helvetica Neue&quot;,Helvetica,Arial,sans-serif;font-size:16px">For the most challenging proteins, AlphaFold scored a median of 87, 25 points above the next best predictions.<b> It even excelled at solving structures of proteins that sit wedged in cell membranes, which are central to many human diseases but notoriously difficult to solve with x-ray crystallography.</b> Venki Ramakrishnan, a structural biologist at the Medical Research Council Laboratory of Molecular Biology, calls the result “a stunning advance on the protein folding problem.”</span>  <br></div><div><br></div>Source: <a href="https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving-protein-structures">https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving-protein-structures</a><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div>--------------------------------------------------------------------------</div><div>Jim Fairman</div><div dir="ltr"><span style="font-size:12.8px">C: 1-240-479-6575</span></div></div></div></div></div></div></div><br></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Mon, Nov 30, 2020 at 10:25 AM lbetts0508 &lt;<a href="mailto:laurie.betts0508@gmail.com">laurie.betts0508@gmail.com</a>&gt; wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div class="gmail_default" style="font-size:large">all - I just read the blurb in Nature Briefing about the DeepMind AI having made a big advance in the CASP protein fold prediction.</div><div class="gmail_default" style="font-size:large"><br></div><div class="gmail_default" style="font-size:large">Does it sound really transformational, does it work for membrane proteins - all the usual questions come to mind.</div><div class="gmail_default" style="font-size:large"><br></div><div class="gmail_default" style="font-size:large">Do we know enough yet about it?  </div><div class="gmail_default" style="font-size:large"><br></div><div class="gmail_default" style="font-size:large">Signed an old protein crystallographer, L. Betts</div></div>
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