<html><head><meta http-equiv="Content-Type" content="text/html; charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div>Our group has an opening for a postdoctoral fellow to be funded on a Cancer Research UK programme aimed at understanding lysosomal control of cell proliferation and stress responses in cancer cells. The programme involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass spectrometry, molecular dynamics as well as other biophysical and biochemical approaches.<br class=""><div class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><br class="">The post will focus on the reconstitution of large signalling assemblies that detect nutritional and stress signals on and off membranes. The candidate will join a vibrant team of researchers investigating structures, regulation, kinetics and dynamics of phosphoinositide 3-kinase family members reconstituted with their regulators on membrane surfaces. This programme concerns regulation of the lipid kinase VPS34 and protein kinase mTOR and ATM-containing complexes. The research combines biochemical, biophysical and cell biological methods with structural approaches. This is a unique opportunity to play a major role in exciting programme, introduce new ideas, and disseminate research results, while working in a collaborative and supportive environment. <br class=""><br class="">The position is available immediately, with an application closing date of 11 April 2022.<br class="">For more details, please see<br class=""><br class=""><a href="https://www.nature.com/naturecareers/job/postdoctoral-scientist-pnac-dr-roger-williams-lmb-1798-mrc-laboratory-of-molecular-biology-755546" class="">https://www.nature.com/naturecareers/job/postdoctoral-scientist-pnac-dr-roger-williams-lmb-1798-mrc-laboratory-of-molecular-biology-755546</a><br class=""><br class=""> Please contact Roger Williams at <a href="mailto:rlw@mrc-lmb.cam.ac.uk" class="">rlw@mrc-lmb.cam.ac.uk</a>, if you have any questions.<br class=""><br class="">Dr. Roger Williams, FMedSci, FRS<br class=""><a href="mailto:rlw@mrc-lmb.cam.ac.uk" class="">rlw@mrc-lmb.cam.ac.uk</a><br class="">MRC Laboratory of Molecular Biology<br class=""><div class="">Francis Crick Avenue<br class="">Cambridge CB2 0QH<br class="">UK<br class="">Phone: +44 1223 267094<br class=""><br class=""><br class=""></div><br class=""></div></div></div><br class=""></body></html>