On Mar 27, 2013, at 12:32 PM, Anastassis Perrakis wrote:

These said, I am rather easily irritated these days, so I will not comment on the irritable character of the email.
...
we will soon start calling disordered loops 
positionally challenged polypeptide segments (*). 

You might want to embrace the power of positive thinking.

Where you see "positionally challenged", an optimist would see "entropically gifted".

James