Opportunity for a Senior/Principal Scientist at Odyssey Therapeutics in Boston MA.
We are seeking a highly motivated and skilled Structural Biologist to join the Odyssey team at our site in Boston where you will be a key contributor to the structural enablement of pipeline discovery projects. You will employ cutting-edge structural techniques such as cryo-EM and X-ray crystallography in a cost-effective, efficient manner. You will use your expertise to better understand mechanisms of action and structural aspects of protein-protein and protein-ligand interactions, and to guide protein therapeutic design. You will oversee the production of quality proteins in support of biophysical and structural analyses. Working closely within therapeutic project teams, you will determine and communicate the structures of both protein-small molecule complexes and multiprotein complexes. In this primarily lab-based role, you will be a key contributor to the application of internal and external resources and capabilities necessary to drive biophysics and structural biology efforts.
More information, including responsibilities and desired skills, can be found at: https://boards.greenhouse.io/odysseytherapeutics/jobs/4538034004
Chip Lesburg
[cid:153156_edd5022b-de61-48a6-bf68-1a41de35ba89.png] Charles Lesburg
Vice President, Structural Biology
M 908-265-2064
301 Binney Street, Cambridge, MA 02142
odysseytx.com
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Dear all,
I am trying to build the model with Alphafold2 using Dock and Rebuild and
encountered some issue with rebuild_predicted_model. It does not rebuild the
model telling that: "Unable to morph model...may not match exactly in chain
ID or residue numbers. No morphed model obtained... No docked model to work
with."
I use the model predicted with Alphafold2 google colab and the cryoem map
with 3.5A resolution boxed around the protein of interest. The
process_predicted_model and dock_predicted_model run successfully, giving
the single-chain model which nicely fits into the map (40 of 300 residues
are excluded due to low LDDT). The chain ID in the docked model is indeed
different from predicted model: the predicted model has one chain A, but the
docked one has A1. However, manually changing the chain ID either in the
predicted or in the docked model does not resolve the issue. Manual runs of
rebuild_predicted_model also fail with the same result.
Tried it with models and maps for different proteins, tried both on Linux
and Windows - it gives the same output (Phenix 1.20.1.-4487). Please, find
the log attached. I am seeking for any advice on resolving this problem.
Best regards
Andrey Moiseenko
Electron Microscopy Lab @ Biology Department
Moscow State University
<mailto:[email protected]> postmoiseenko(a)gmail.com
skype: callmoiseenko
