refinement {
  main {
    nproc = 4
  }
  refine {
    strategy = individual_sites rigid_body individual_adp \
    group_adp tls occupancies group_anomalous *den
  }
  den {
    reference_file = none
    gamma = 0.0
    kappa = 0.1
    weight = 300
    sigma = 0.44
    optimize = true
    opt_gamma_values = 0 0.2
    opt_weight_values = 100 300
    num_cycles = 2
    kappa_burn_in_cycles = 2
    bulk_solvent_and_scale = True
    refine_adp = False
    final_refinement_cycle = False
    verbose = True
    annealing_type = *torsion cartesian
    output_kinemage = False
    restraint_network {
      lower_distance_cutoff = 5
      upper_distance_cutoff = 20
      sequence_separation_low = 0
      sequence_separation_limit = 10
      exclude_hydrogens = True
      ndistance_ratio = 1
      export_den_pairs = False
      den_network_file = None
    }
  }
  tardy {
    mode = every_macro_cycle second_and_before_last *once first first_half
    start_temperature_kelvin = 3300
    final_temperature_kelvin = 300
    number_of_cooling_steps = 1440
    number_of_time_steps = 1
    time_step_pico_seconds = 0.001
    prolsq_repulsion_function_changes {
      c_rep = 100
      k_rep = 1
    }
  }
  simulated_annealing {
    start_temperature = 3300
    final_temperature = 300
    cool_rate = 50
    number_of_steps = 24
    time_step = 0.001
  }
}