Dear all, Registration is open for the 2024 CCP4 study weekend entitled "Decision making in MX - how to be a productive structural biologist". Important Key Dates: * Early bird registration final date: 19 November 2023; * We have assisted places available for students registering during early bird period i.e. now until 19 November - which cover the cost of registration plus one night accommodation meaning students only pay for aqdditional nights accommodation @ £63 per night; * Registration for in-person delegates closes 4 December 2023 (or earlier if in-person places sell out although you will be able to join the in-person waitlist). This year we are focusing on decision-making in macromolecular crystallography: when to use what automated tool, how to interpret the output and when you need to get your hands dirty instead. The frontiers of crystallography now involve massive multi-crystal and multi-dimensional experiments. This means the more that you can leave to the automated pipelines, the more you can focus on the novel elements of your experiment. Sometimes those automated tools work, and sometimes they fail (but have maybe not told you exactly why or how). Sometimes they don't even exist. In that case, how can you return to the basics and develop new strategies to break down the barriers to publication? Once again, this year the CCP4 Study Weekend will be held as a hybrid event from the 3rd to 5th January 2024, enabling people to choose whether to attend in-person or virtually. The in-person event will be held at the East Midlands Conference Centre, Nottingham, UK. We would like to invite you to another iteration of the ever-popular CCP4 Study Weekend - to start the year 2024 with a lot of fresh ideas, new insights and (hopefully) new friends and contacts to boost. As always it will be an eclectic mix of bleeding-edge science, in-depth presentations, discussion panel, poster-sessions, hands-on tutorials and plenty of opportunities for social interactions including the ceilidh. For full details, programme, logistics and registration, please visit the Study Weekend websitehttps://studyweekend.ccp4.ac.uk/. Sessions will cover: Day 1 Diamond MX User Meeting Session 1: Key note talk Discussion panel - "Crystallography is dead - long live Crystallography!" Day 2 Session 2: Preparation and data collection: Planning and execution of diffraction experiment Session 3: Structure Solution & Model Building (post-AlphaFold) Session 4: The important final touches: Modelling Subtle / Difficult Structural Features Day 3 Session 5: Weak Signal / Large Datasets: Partial Data and Partial Occupancies Session 6: Experimental Interactions: Ligands, everywhere, all at once Session 7: Structural Analysis: Climbing the data mountain Speakers include: Ashwin Chari (Max Planck Institute for Multidisciplinary Sciences, GERMANY) Tristan Croll (Altos Labs, UK) Ed Daniel (University of Oulu, FINLAND) Judit Debreczeni (AstraZeneca, UK) Elke de Zitter (Institut de Biologie Structurale, FRANCE) Kamel El Omari (Diamond Light Source, UK) Paul Emsley (UKRI-MRC LMB, UK) Elspeth Garman (University of Oxford, UK) Rasmus Fogh (Global Phasing Ltd, UK) Dorothee Liebschner (Lawrence Berkeley National Laboratory, USA) Garib Murshudov (UKRI-MRC LMB, UK) Arwen Pearson (Center for Free-Electron Laser Science - CFEL, GERMANY) Patrick Reinke (Deutsches Elektronen-Synchrotron, DESY, GERMANY) Lucy Schofield (University of York, UK) Oliver Smart (Global Phasing Ltd, UK) Graeme Winter (Diamond Light Source, UK) Briony Yorke (University of Leeds, UK) We hope to see you there! Scientific Organisers: Helen Ginn (Deutsches Elektronen-Synchrotron, DESY, Germany) Nick Pearce (Linköping University, Sweden) Clemens Vonrhein (Global Phasing Ltd, UK) Administrative Organisers: Karen McIntyre (CCP4, UK)