For the most challenging proteins, AlphaFold scored a median of 87, 25
points above the next best predictions.* It even excelled at solving
structures of proteins that sit wedged in cell membranes, which are central
to many human diseases but notoriously difficult to solve with x-ray
crystallography.* Venki Ramakrishnan, a structural biologist at the Medical
Research Council Laboratory of Molecular Biology, calls the result “a
stunning advance on the protein folding problem.”
Source:
https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving...
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Jim Fairman
C: 1-240-479-6575
On Mon, Nov 30, 2020 at 10:25 AM lbetts0508
all - I just read the blurb in Nature Briefing about the DeepMind AI having made a big advance in the CASP protein fold prediction.
Does it sound really transformational, does it work for membrane proteins - all the usual questions come to mind.
Do we know enough yet about it?
Signed an old protein crystallographer, L. Betts _______________________________________________ phenixbb mailing list [email protected] http://phenix-online.org/mailman/listinfo/phenixbb Unsubscribe: [email protected]