Hi Peter,
Refinement of severely partial models can be greatly
facilitated by some way of describing the missing parts or at least
knowing were there is solvent and where protein.
Some of these points are described in "Refinement of severely
incomplete structures with maximum likelihood in BUSTER-TNT"
E. Blanc, P.
Roversi, C.
Vonrhein, C.
Flensburg, S.
M. Lea and G.
Bricogne (2004) Acta Cryst. (2004). D60, 2210-2221.
I agree. But if I remember correctly, they set up some a priori
information in these areas and not just leave them empty. So when you
let bulk solvent fill in these areas you assume that there is some
density there, otherwise you assume that there is nothing there (which
I guess is worse).
Pavel.