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3 May
2012
3 May
'12
10:23 a.m.
On Thu, May 3, 2012 at 10:05 AM, Dale Tronrud
An important point is that the Fc's must never be used to judge the quality of the Fo's in a production environment.
I'm not sure that's completely fair - they can certainly be used to identify Fobs values that are wildly at odds with expectations. This is what Pavel does with outlier rejection in phenix.refine (I forget the exact reference for this protocol but I think it's Read 1999 or something like that). The difference, I think, is one of degree, and also that (at least in the current version) the outliers are recalculated at each cycle of refinement and never permanently excluded, unlike anisotropic truncation. -Nat