![](https://secure.gravatar.com/avatar/cad35f4dd77b3ab8e60ede4e3d54c6f4.jpg?s=120&d=mm&r=g)
7 Dec
2012
7 Dec
'12
10:17 p.m.
On Fri, Dec 7, 2012 at 1:54 PM, Douglas Theobald
Maybe I've misunderstood, but Karplus and Diederichs used phenix in their paper arguing for including weak data. Whether the benefit they describe is considered cosmetic or non-trivial, it at least appears that including very weak data doesn't hurt. At least with phenix.
Yes, I forgot to mention this. I suspect that most other modern refinement programs, which all use maximum likelihood targets (but with various differences), would behave similarly. -Nat