Hi Tim,

It looks like you’ll need to navigate a bit of a learning curve using the available online resources (rather than me re-typing everything here!). Here are some useful pointers:

1) Phenix Video Tutorials:
https://www.youtube.com/c/phenixtutorials
There are several relevant tutorials on model building.

2) Self-Guided Tutorials:
Phenix comes with built-in tutorials, including many focused on model building. You’ll see examples of how to use them in the video tutorials mentioned above.

3) Phenix Documentation:
https://phenix-online.org/documentation/
It provides plenty of detailed guidance and references.

4) Workshops for Hands-On Experience. Consider attending one of upcoming workshops with Phenix experts:

- ACA Satellite Phenix Workshop (Summer 2025);
- Week-long Crystallography & Cryo-EM School in Madrid (Spring 2025);
- Mini Phenix Workshop at the West Coast Structural Biology Meeting (Spring 2025);
...and I’m sure more will be coming in 2025.

Please reach out if you have specific questions that aren’t covered in these resources.

Good luck!
Pavel


On 12/18/24 09:49, tim smith wrote:

Hi all,

Can you please advise once we fit the map and open in coot. What is next step to do in coot. I tried refmac but that required ccp4 file which doesn't have. Please some one can help in elaborating and sharing any tutorial would be helpful. I'm new bie and first time I am trying model building. Any help would be really appreciated. Thank you so much
Best wishes
Tim


On Tue, 17 Dec 2024, 13:47 Oleg Sobolev, <[email protected]> wrote:
Hello Iram,

The general workflow for Cryo-EM is described here:
https://phenix-online.org/documentation/overviews/cryo-em_index.html

It looks like you are ready to refine your model, so the tool for it is phenix.real_space_refine:
https://phenix-online.org/documentation/reference/real_space_refine.html
that also has a video tutorial.

Let us know if you have any questions.

Best regards,
Oleg Sobolev.

On Thu, Dec 12, 2024 at 5:54 PM iram aziz <[email protected]> wrote:
Hello All.
      I got a nice 2.45 Angstrom map from cryo em data. I checked handedness, map model fitting on the chimera and opened in the coot. It looks nice. Can you please give me suggestions about the Phenix refinement steps.
Thanks
Iram
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