On Fri, Nov 14, 2014 at 2:06 PM, Dale Tronrud <detBB@daletronrud.com> wrote:

You also asked if burning your crystals could improve the map. If
you have more crystals I would recommend soaking them in a higher
concentration of ligand. No amount of fancy data collection is going
to make the density of a low occupancy compound stronger. Getting the
occupancy up will do you worlds of good.

But won't measuring the weak high-resolution reflections as accurately as possible help resolve map details like partial-occupancy atoms? (Although I think it's better to do this by collecting more redundant data than increasing the exposure time.)

-Nat