Dear all,
(Apologies for the slightly off-topic cross-post - hopefully, this will be of interest to all MX practitioners, not just Diamond light source users.)
As Diamond User Committee MX representatives, we'd just like to remind you that the deadline for letters of support for Diamond-II beamline upgrades is this Friday, 20th November.
As you are perhaps aware, the Diamond machine is scheduled for a major upgrade to a 4th generation source 2025-2027.
Further information about the upgrade can be found
here.
All MX beamlines will benefit from a brighter, more focused source – however, two MX beamlines have been selected as flagship projects for significant upgrades.
I04-1 > K04 Ultra XChem.
The I04-1 fixed wavelength beamline used for the XChem fragment screening will be completely rebuilt as K04.
Briefly, K04 will allow higher throughput fragment screening (meaning more projects and more fragments can be screened) and it is hoped the improved characteristics of the Diamond-II beam will allow XChem methodologies to be extended to more difficult targets
such as transmembrane proteins.
The K04 proposal outline can be found
here [PDF].
I24 > KMX Kinetic micro crystallography.
The I24 microfocus beamline will be upgraded to enhance the capabilities of I24 and allowing analysis of smaller crystals, radiation-sensitive crystals, and expanding the serial synchrotron crystallography (SSX) functionality of the beamline. The abilities
to conduct room temperature SSX will also be enhanced to allow in-crystal kinetic analysis, with various on-line spectroscopic (Raman, UV-Vis, XES) detectors built into the end station.
The KMX proposal outline can be found
here [PDF]
Having read these proposals you will obviously be very excited by the possibilities and will want to submit your letters of support for both of them, by
Friday, 20th November
Letters of support can be submitted via this link.
Thanks in advance,
Dave & Arnaud.
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