Berkeley Lab's Molecular Biophysics and Integrated Bioimaging Division
http://biosciences.lbl.gov/divisions/mbib/ is looking for a Computational
Biologist Postdoctoral Fellow to work in the Sauter group. We are seeking
an algorithm developer for the increasingly complex analysis of large
diffraction datasets in structural biology. Current projects utilize XFEL
crystallography and spectroscopy to investigate the photosynthetic
mechanism of water splitting and to probe other metalloenzyme reactions.
We also wish to test whether diffuse scattering can reveal correlated
atomic motions in crystals. Many problems remain to be solved, including
the details of how to optimally merge datasets from thousands of crystals.
Our software development projects (including packages such as DIALS
http://dials.lbl.gov and cctbx.xfel http://cci.lbl.gov/xfel) have been
highlighted in several high-impact publications listed HERE
http://biosciences.lbl.gov/profiles/nicholas-sauter.
Candidates should have expertise in one or more computational techniques
including, but not limited to, ray tracing to test underlying physical
models of the diffraction, Bayesian approaches for refining model
parameters, macromolecular modeling and refinement, neural networks for
interpreting image features, as well as signal processing and denoising
methods. Extensive data analysis experience in crystallography or from
more general bioimaging backgrounds are welcome. We particularly encourage
strong mathematical intuition and a track record of bringing new ideas and
tools to fruition, as evidenced through written publication and clear
presentation.
Candidates should send an expression of interest, CV, and list of three
references to *Nick Sauter, [email protected]