Hi all,

I'm very happy to announce the release of ISOLDE 1.2, now available for installation into the ChimeraX 1.2 release. To get it, first download and install ChimeraX 1.2 from https://www.rbvi.ucsf.edu/chimerax/download.html, then go to "Tools/More Tools..." in the menu and follow the links to install ISOLDE. Key new features include:

• The ability to add residues to the ends of protein chains (see https://twitter.com/CrollTristan/status/1391747032579289089?s=20; support for nucleic acid chain extension still in development)
• Lower-fidelity simulation modes for greatly improved performance on lower-end GPUs (see https://twitter.com/CrollTristan/status/1390709520876331009?s=20)
• Commands to write input files for phenix.refine and phenix.real_space_refine with recommended settings for refining models from ISOLDE
• Command to write a ProSMART-like restraint definition file to softly restrain the model to its current geometry in Refmac
• Improvements to stability and performance of bulk solvent/scaling in crystallographic datasets
• Short aliases for commonly-used commands to make life easier for power users.