But how about if both the Rfree and Rwork decrease, by comparing the start and final, however in the middle of the the refinement (for example the second cycle of the default3 cycles) the Rfree and Rwork are higher in comparison with the Rfree_start and Rwork_statrt?

Cheers,

Dialing

From: Terry Lang <[email protected]>
To: PHENIX user mailing list <[email protected]>
Sent: Tuesday, 7 February 2012 12:13 PM
Subject: Re: [phenixbb] on Rwork and Rfree

Did you use the R-free values from the previous refinement? If you generated a new set, that can influence both values.

On Mon, Feb 6, 2012 at 6:07 PM, Nathaniel Echols <[email protected]> wrote:

On Mon, Feb 6, 2012 at 6:01 PM, Dialing Pretty <[email protected]> wrote:
> Rfree increases from 0.2633 to 0.2668.

Okay, that makes more sense. However, unless there is substantial
improvement in geometry (and maybe not even then), I still don't think
this is a good result. It's difficult to know for sure without seeing
the "before" and "after" models.

-Nat
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