Great paper indeed! 

However quite significant progress seems to have been achieved with ligands (and not only)...https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/ 
Has anyone in the community put this to the test? 


Best wishes
Roberto



Roberto A Steiner
www.steinerlab.org
 
Randall Centre for Cell and Molecular Biophysics 
Faculty of Life Sciences and Medicine                  
King's College London            
Room 3.10A
New Hunt's House, Guy's Campus
SE1 1UL, London, UK
Phone 0044 20 78488216
Fax    0044 20 78486435

[email protected]
Dipartimento di Scienze Biomediche
Università degli Studi di Padova
Viale G. Colombo 3
35131 Padova, Italia
Telefono 0039 049 8276409
 
Responses to emails are not expected outside of your normal working hours.








On 30 Nov 2023, at 22:35, Tom Terwilliger <[email protected]> wrote:

Hi Structural biologist colleagues!  

Our article that helps you make the case that the experiment is still very much needed is now out:

https://www.nature.com/articles/s41592-023-02087-4

"AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination."  Nature Methods (2023)

Also, here is a video on the Phenix Tutorials YouTube channel that describes this analysis:  https://www.youtube.com/watch?v=ugMPYdPo8Bc

(I hope you will be happy to see that you and your structural biology colleagues get the credit for making AlphaFold possible at 2:35 in the introduction of this video!  Keep up the fantastic structural biology work!)

All the best,
Tom T
--
Thomas C Terwilliger
Laboratory Fellow, Los Alamos National Laboratory
Senior Scientist, New Mexico Consortium
100 Entrada Dr, Los Alamos, NM 87544
Tel: 505-431-0010


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