Hi Carlos,
Normally if you apply a B-sharpen of 220 to a 3 Å map, the new map should look really different from the original map (no matter whether you do it yourself or autosharpen does it). So best guess is that something is not happening the way you would like it to be.
A suggestion: run the quick autosharpen tutorial data supplied with Phenix. Presumably it will work normally. Then tell autosharpen to blur that map to 300 A**2. This map should look something like your map (does it?). Now apply autosharpen to the blurred map. It should apply a B-sharpen of about 250 or so (does it?). And the new blurred - then - sharpened map should look good.
Let me know if that doesn't work!
All the best,
Tom T