Hi everyone,

The heavy atoms(Se-Met) were located at P4322 space group(4A). But the initial density map is so bad that I can not build the initial model.

Meanwhile, I have another two datasets, native(2.6A) and  se-met anomalous dataset with space group P2221. But these two datasets have no solution. I have tried the initial map from sp P4322 as a model to do molecular  replacement. But no MR solution. 

So, I want to know how can I use the heavy atom as model to do MR with isomorphous or anomalous differences?

Thanks!