On Tue, Jun 15, 2010 at 4:03 PM, Francis E Reyes <Francis.Reyes@colorado.edu> wrote:
Using the model to find the heavy atom sites and then calculating phases on those sites (without model) might help. ( I believe phenix will output a phase combined map (model + experimental phases)).

Correct, this is the default behavior if you provide a model directly to AutoSol (or Phaser).  There is however a semi-automatic way to use the model phases to find sites without biasing the experimental map; see the documentation here:

https://www.phenix-online.org/version_docs/1.6.2-432/autosol.htm#anch126

(The AutoBuild step is optional - you could just look at the density-modified map after AutoSol is done.)

-Nat