I was wondering what would be current best protocols for trying to improve maps/phases for low resolution
MR / refinement solutions (5-6 Å resolution).
High solvent content of course, dimeric 2:2 protein complex so some NCS averaging and density modification
I assume might help (related structures known, currently maps very blobby, clear solution but I think should be able to do better...).
Also, refinement suggestions welcome.
Best route in phenix? So far worked initially with ccp4. Other suggestions also welcome.
Thanks!
Tommi