Re: [phenixbb] alpha-Fold 2?

To this point: How do you KNOW the structure is on par UNLESS you have the experimental result?

On 30 Nov 2020, at 3:22 PM, Frank Von Delft wrote:

"Scores above 90 on the zero to 100 scale are considered on par with experimental methods, Moult says."

Who is it that does the considering for us? Great that it's good enough to make molecular replacement work (VERY great!!!!) - but "on par" is a big word.

Sent from tiny silly touch screen http://www.9folders.com/ From: Jim Fairman Sent: Monday, 30 November 2020 19:58 To: lbetts0508 Cc: PHENIX user mailing list Subject: Re: [phenixbb] alpha-Fold 2?

For the most challenging proteins, AlphaFold scored a median of 87, 25 points above the next best predictions. It even excelled at solving structures of proteins that sit wedged in cell membranes, which are central to many human diseases but notoriously difficult to solve with x-ray crystallography. Venki Ramakrishnan, a structural biologist at the Medical Research Council Laboratory of Molecular Biology, calls the result “a stunning advance on the protein folding problem.”

Source: https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving... https://www.sciencemag.org/news/2020/11/game-has-changed-ai-triumphs-solving... -------------------------------------------------------------------------- Jim Fairman C: 1-240-479-6575

On Mon, Nov 30, 2020 at 10:25 AM lbetts0508 mailto:[email protected]> wrote: all - I just read the blurb in Nature Briefing about the DeepMind AI having made a big advance in the CASP protein fold prediction.

Does it sound really transformational, does it work for membrane proteins - all the usual questions come to mind.

Do we know enough yet about it?

Signed an old protein crystallographer, L. Betts _______________________________________________ phenixbb mailing list [email protected] mailto:[email protected] http://phenix-online.org/mailman/listinfo/phenixbb http://phenix-online.org/mailman/listinfo/phenixbb Unsubscribe: [email protected] mailto:[email protected]_______________________________________________ phenixbb mailing list [email protected] http://phenix-online.org/mailman/listinfo/phenixbb Unsubscribe: [email protected]

Patrick Loll [email protected]