Hello every one,<BR>&nbsp;<BR>Did any of you experience the problem 'MemoryError' when doing phenix.refine? I had a perfect twin case and I used phenix refine to handle this. But I&nbsp; have met the problem 'MemorryError' and the refinement was stalked after long time running of phenix. Here is the basic info: <BR>Resolution 2.2A<BR>space group f23<BR>the protein size ~320AA<BR>my computor memory 4GB.<BR>If someone is kind enough to really help, I can send her/him the log file.<BR>Yingjie<BR>&nbsp;<BR>&nbsp;