Hi!<br> I have probably a very naive question -<br><br>when one includes hydrogens into a refinement of a model build with data at ~3.6A  clash score should not go up?<br><br>I mean I am including hydrogens for a reason of improving the model quality when I cannot fit the sidechains into some density, etc. Can it be true that using default 3 macrocycles on a changed (reduced) model is not enough to minimize it?<br>
<br>Thanks,<br>Tanya<br>