Hi Keitaro,
During refinement with twin_law, the log file says x-ray target function is set to "twin_lsq_f". Does it mean, we cannot use maximum likelihood target for twinned data? If so, is it recommended to refine without twin_law at first several cycles?
I have never done a systematic study to answer this question. How good is your model?
When I tried to refine using the model refined without twin_law, the target function was still ml, not twin_lsq_f although I specified twin_law. Is this a bug?
Not sure, can you send (off-list) logfile of that run?
When I used twin_law option, in the table "R-free likelihood based estimates", "Scale factor" were None in all resolution bins. Cannot scale factor be calculated during twin refinement?
The scale factor (one per dataset) is refined during twin refinement and subsequently fixed during positional and adp refinement. The lsq_twin target function doesn't have a resolution dependent scale factor.
Thanks in advance and Wishing you the best holidays,
Same to you! HTH P
Keitaro
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