Yeah, I didn't want to go there but I'd say 95% is user error (for the XDS option). On the other hand XDS will process whatever junk you provide it. sometimes it's worth looking at the various logfiles etc. Jürgen P.S. I feel the flames already form HKL-folks On May 8, 2012, at 11:58 AM, Kay Diederichs wrote: On May 8, 2012, at 11:11 AM, Zhou, Tongqing (NIH/VRC) [E] wrote: Hi J?rgen, Kelly and Nat, I tried XDS and MosFilm, they simply cannot index the data. Hi, "simply cannot index" is hard to believe. 90% of indexing failures are due to wrong header values, 9% to the spindle rotating in the "wrong" direction, and the last 1% has other causes. I have yet to see a single-crystal dataset that cannot be indexed. If you are willing to confidentially share (at least some of) your data, I could try to process them with XDS - at least you get another opionion. Easiest way: copy them into a Dropbox or Wuala folder and share that. best, Kay _______________________________________________ phenixbb mailing list [email protected]mailto:[email protected] http://phenix-online.org/mailman/listinfo/phenixbb ...................... Jürgen Bosch Johns Hopkins University Bloomberg School of Public Health Department of Biochemistry & Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Office: +1-410-614-4742 Lab: +1-410-614-4894 Fax: +1-410-955-2926 http://web.mac.com/bosch_lab/