I am in the process of solving a series of protein/ligand complex structures and ran the Polygon tool on the series.  I noticed that, in general, even when all the other statistics were good, the B(sol) term was a bit too high according to Polygon. (The structures with poorer statistics also had high B(sol) values as well.) Since this is a series of multiple structures of the same protein, should this be a concern for me? And if so, what are typical causes of a high B(sol) value?<br>
<br>Matt Merski<br>Shoichet Group<br>UCSF<br>