I need to create a phosphodiester bond between O3’ of a DNA nucleotide and P of a 3DR HETATM ligand (a modified nucleotide). I also need to delete O3P of the 3DR nucleotide. How can I create this restraint?

Also, how can I get COOT to display this bond?

Thanks,

Mark

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Mark A. Saper, Ph.D.

Dept of Microbiology and Molecular Genetics

Hebrew University Faculty of Medicine

[email protected] | +972 52 815-0480