Hi Felix,

Hi Pavel
According to your mail from yesterday I wonder how can I treat Ramachandran outliers in very large molecules (close to 9000 residues).

- fix them manually first and then run refinement;
- if after refinement some of them come back as outliers then you consider them for including into Ramachandran restraints.

Ramachandran restraints are good at keeping correct conformation from becoming an outlier (due to poor density for instance), and NOT for fixing wrong one.

Pavel