Dear Colleagues A reminder that the Cold Spring Harbor Macromolecular Crystallography course will take place October 11-27th this year (pleased see below for more details, with an extended deadline of August 14th). This comprehensive course is an outstanding place to learn both the theoretical and practical aspects of macromolecular crystallography. There are extensive lectures and practical sessions from world recognized experts in crystallization, data collection, data processing, structure solution, refinement, and validation. The goal of the course is for researchers who have had some exposure to structural biology to become experts in crystallography. This is an experience in macromolecular crystallography learning that cannot be found anywhere else, and the student/teacher ratio is often 1:1. Please follow the link below to the course web site. In particular, please note the information about the various fellowships, scholarships, and stipends that are available. Many applicants ultimately receive some form of financial support. If anyone has any questions please send me an e-mail, and we will be happy to answer all queries. Paul Adams, Dorothee Liebschner, Janet Newman, James Pflugrath, Tom Peat https://6zadfgnab.cc.rs6.net/tn.jsp?f=001vX26f7F6RuZoXG6GBghaPG6Gmt5I2bQPqwmSzzY8Nv6fpwotETJRFVzfRlv-Ric5jdBYw6pJ_x2M-2o_EujiArEELpm2-Ric1rbiB7YDN12N7UGNpxSyAPTlZVosyiwJ7tA5tKAd9HD5aaocz1dpcZeYWizvotPC&c=3TmapiwCc145JAQCOHm899-1vDcKsSTtKsTFjnVr-yDxWKzrcuAZSA==&ch=Pme851w1_FlobvCfTQguUvp-wdf7HADJ0tN6uMPteDJCSdQTWkWyGQ== https://6zadfgnab.cc.rs6.net/tn.jsp?f=001vX26f7F6RuZoXG6GBghaPG6Gmt5I2bQPqwmSzzY8Nv6fpwotETJRFYtrHSl8m2qvnQJSfV5JJsnZNbzEW-nFOQlVpnqZUIjer0CHtvEXlK0vpf8wZRjn_cUvkJx_USzTyGolETB2OVU7gGw-aGqL-KUA-AarHw0m5SX57YrWPIFJqlNrFdk202T7CKH40lGSVk5nQ4UNmY8=&c=3TmapiwCc145JAQCOHm899-1vDcKsSTtKsTFjnVr-yDxWKzrcuAZSA==&ch=Pme851w1_FlobvCfTQguUvp-wdf7HADJ0tN6uMPteDJCSdQTWkWyGQ== Macromolecular Crystallography https://6zadfgnab.cc.rs6.net/tn.jsp?f=001vX26f7F6RuZoXG6GBghaPG6Gmt5I2bQPqwmSzzY8Nv6fpwotETJRFYtrHSl8m2qvnQJSfV5JJsnZNbzEW-nFOQlVpnqZUIjer0CHtvEXlK0vpf8wZRjn_cUvkJx_USzTyGolETB2OVU7gGw-aGqL-KUA-AarHw0m5SX57YrWPIFJqlNrFdk202SKF56a6dxr9ExJ-bcQe-s=&c=3TmapiwCc145JAQCOHm899-1vDcKsSTtKsTFjnVr-yDxWKzrcuAZSA==&ch=Pme851w1_FlobvCfTQguUvp-wdf7HADJ0tN6uMPteDJCSdQTWkWyGQ== October 11 - 27, 2026 Applications Due: August 14 Instructors Paul Adams, Lawrence Berkeley National Laboratory Dorothee Liebschner, Lawrence Berkeley National Laboratory Janet Newman, UNSW, Australia James Pflugrath, Rigaku Americas Corporation (ret.), Texas Co-Instructor Tom Peat, UNSW, Australia X-ray crystallography has been the cornerstone of structural biology for half a century and remains the technique of choice for atomic resolution understanding of macromolecules and for structure guided drug discovery. This course combines laboratory and computational instruction to train course participants in the major techniques used to determine three-dimensional structures. It is designed for scientists with a working knowledge of protein structure and function, but who are new to macromolecular crystallography or who wish to increase their in-depth knowledge of macromolecular crystallography. The advent of methods for the accurate prediction of protein structures is accelerating crystallography experiments, and the course will train researchers in how to best use these models. Topics Basic Diffraction Theory Structure Presentation Coordinate Deposition Structure Validation Model Building and Refinement Electron Density Maps Improvement Using Predicted Models in Structure Solution and Completion Protein Structure Prediction Structure Solution by Experimental Phasing Methods (SAD, MAD, MIR, and others) and Molecular Replacement Data Collection and Processing Synchrotron X-ray Sources and Optics Crystallization (Proteins, Nucleic Acids, Complexes and Membrane Proteins) Participants have extensive hands-on training in well-equipped labs in how to crystallize proteins and determine crystal structures by several methods, while learning through lectures on theory and methods. Both basic and advanced subjects are covered during lectures, which are given by leaders in the field. Informal discussions behind the techniques are frequent and students are expected to pose questions to be answered in interactive sessions. For further information and to apply please visit the Macromolecular Crystallography course website. https://6zadfgnab.cc.rs6.net/tn.jsp?f=001vX26f7F6RuZoXG6GBghaPG6Gmt5I2bQPqwmSzzY8Nv6fpwotETJRFYtrHSl8m2qvnQJSfV5JJsnZNbzEW-nFOQlVpnqZUIjer0CHtvEXlK0vpf8wZRjn_cUvkJx_USzTyGolETB2OVU7gGw-aGqL-KUA-AarHw0m5SX57YrWPIFJqlNrFdk20zfTIy2Xy7e6lttC49yapj8=&c=3TmapiwCc145JAQCOHm899-1vDcKsSTtKsTFjnVr-yDxWKzrcuAZSA==&ch=Pme851w1_FlobvCfTQguUvp-wdf7HADJ0tN6uMPteDJCSdQTWkWyGQ== Cold Spring Harbor Laboratory - Meetings & Courses | 1 Bungtown Road | Cold Spring Harbor, NY 11724 US Unsubscribe https://visitor.constantcontact.com/do?p=un&m=001S3f9XM7Br7nKhcnZ-APDwA==&ch=5f75c3d0-c591-11e3-b735-d4ae52843dc7&ca=0307bd81-682b-4a76-8503-2d97e6b68ff4 | Update Profile https://visitor.constantcontact.com/do?ch=5f75c3d0-c591-11e3-b735-d4ae52843dc7&t=001s2g8aFnqQN8lfGj4FefPiw==&lang=001FCSs65SMrsI=&m=001S3f9XM7Br7nKhcnZ-APDwA==&p=oo&ca=0307bd81-682b-4a76-8503-2d97e6b68ff4 | Constant Contact Data Notice https://www.constantcontact.com/legal/customer-contact-data-notice -- Paul Adams (he/him/his) Associate Laboratory Director for Biosciences, LBL (https://biosciences.lbl.gov) Principal Investigator, Computational Crystallography Initiative, LBL (http://cci.lbl.gov) Vice President for Technology, the Joint BioEnergy Institute (http://www.jbei.org) Principal Investigator, ALS-ENABLE, Advanced Light Source (http://als-enable.lbl.gov) Adjunct Professor, Department of Bioengineering, UC Berkeley (http://bioeng.berkeley.edu) Member of the Graduate Group in Comparative Biochemistry, UC Berkeley (http://compbiochem.berkeley.edu) Building 91, Room 410 Building 978, Room 4126 Tel: 1-510-486-4225 http://cci.lbl.gov/paul ORCID: 0000-0001-9333-8219 Lawrence Berkeley Laboratory 1 Cyclotron Road BLDG 91R0183 Berkeley, CA 94720, USA. Executive Assistant: Michael Espinosa [ [email protected] ][ 1-510-333-6788 ] Phenix Consortium: Ashley Dawn [ [email protected] ][ 1-510-486-5455 ] --