Dear Colleagues, The July 16th deadline for applications to the CSHL X-ray Methods in Structural Biology Course to be held later this year, October 4 through October 19, 2021 is rapidly approaching. Please see the attached announcement, and the official course web site is here: https://meetings.cshl.edu/courses.aspx?course=C-CRYS&year=21 please pass this on to folks who might be interested and who would benefit. The course is designed for researchers who are either new to, or who wish to increase their in-depth knowledge of, macromolecular crystallography. We anticipate holding the course in person as long as the pandemic situation continues to improve. Appropriate COVID-19 precautions will be followed to ensure the safety of all participants. Everyone will be required to provide documentary proof of a prior FDA or EMA approved vaccine. This immersive course is an outstanding place to learn both the theoretical and practical aspects of Macromolecular Crystallography because of the extensive lectures from world-renowned teachers, which are combined with hands-on experiments. This 2021 course will be lead by Jim Pflugrath (Rigaku, ret.), Tassos Perrakis (NKI), Paul Adams (LBL), Janet Newman (CSIRO), Tom Peat (CSIRO) and an All-Star cast of lecturers. Attendees can expect to participate in a course that is unparalleled in the world, with experts each devoting several days to teaching the fundamentals, theory and practical considerations of crystallographic structure solution. We expect to have the participants crystallize several proteins and determine their structures all in about two weeks. Students may also work on their own projects, but not exclusively. They will also become well-versed in the theory of X-diffraction and crystal structure determination while having lots of fun, but not much sleep. There will be data collection at state-of-the-art beamlines at NSLS-II. The course is limited to 16 participants due to the very hands-on nature of the experiments and the intimate seminar room and laboratory settings. Please check the above web link for more details. In particular, please note the information about fellowships, scholarships, and stipends that are available. It is often possible for applicants to receive some level of support to help offset the course fee. This course is supported with funds provided by the National Institute of General Medical Sciences for which we are extremely grateful. Also there are stipends available from the Leona M. and Harry B. Helmsley Charitable Trust and the Howard Hughes Medical Institute to help offset the cost of tuition. Scholarship support is provided by Regeneron Pharmaceuticals. If anyone has any questions, please send me e-mail, I will be happy to answer any queries. Thanks for spreading the word, Janet, Tom, Tassos, Paul, and Jim

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From: Cold Spring Harbor Laboratory Meetings & Courses Subject: Macromolecular Crystallography - CSHL Course Date: June 24, 2021 at 5:20:20 AM PDT To: [email protected] Reply-To: [email protected]

https://r20.rs6.net/tn.jsp?f=001eym31bmCvuxG3gZdQKD4XByq24-SM132UB2keWmTzFcYTJsNKVNY4dm1_PgW5qo-99nzCvbE23iV0E2YZjPvhwkoJmzfNJ2ppgqkDbU8Y0VmMrYTKDSFMfyrK8a16li3ZSccjoNR3cq3IbAflINucALxjm0gJVOQ&c=f6-XRY5ZwGsmnf8lQOl7zXzDW0qRVcpgqB0oaHmDdl1pE2O99AwCcA==&ch=q7ShevqbNThKJM_fcxc76rhMcFKTjc0vPsYuk4J_SaEutikLx0acdg== https://r20.rs6.net/tn.jsp?f=001eym31bmCvuxG3gZdQKD4XByq24-SM132UB2keWmTzFcYTJsNKVNY4eHzXSq4U43Qr4KZxVRbZZjZEneOcWJWRN45Ql8y0KKYUEMC3NmHp-IIUOZZSlg4TcGTnaLm3xETiv9uO2Q45sD9xUugNyAH-EXSEJqXiuwQ4ZHEIhbgNEMOuWNx3cjj-ijP7tkOLUiDLV1GVUInH-I=&c=f6-XRY5ZwGsmnf8lQOl7zXzDW0qRVcpgqB0oaHmDdl1pE2O99AwCcA==&ch=q7ShevqbNThKJM_fcxc76rhMcFKTjc0vPsYuk4J_SaEutikLx0acdg== Macromolecular Crystallography https://r20.rs6.net/tn.jsp?f=001eym31bmCvuxG3gZdQKD4XByq24-SM132UB2keWmTzFcYTJsNKVNY4eHzXSq4U43Qr4KZxVRbZZjZEneOcWJWRN45Ql8y0KKYUEMC3NmHp-IIUOZZSlg4TcGTnaLm3xETiv9uO2Q45sD9xUugNyAH-EXSEJqXiuwQ4ZHEIhbgNEMOuWNx3cjj-ijP7tkOLUiDLV1GVUInH-I=&c=f6-XRY5ZwGsmnf8lQOl7zXzDW0qRVcpgqB0oaHmDdl1pE2O99AwCcA==&ch=q7ShevqbNThKJM_fcxc76rhMcFKTjc0vPsYuk4J_SaEutikLx0acdg== October 4 - 19, 2021 Application & Materials Deadline: July 16 We anticipate that the vaccine situation may sufficiently improve to allow us to offer this course safely in-person.

All participants will be required to provide documentary proof of a prior FDA or EMA approved vaccine. Instructors Janet Newman, CSIRO, Australia (likely remote) James Pflugrath, Rigaku Americas Corporation (ret.), Texas Anastassis Perrakis, Netherlands Cancer Institute Paul Adams, Lawrence Berkeley National Laboratory Co-Instructor: Tom Peat, CSIRO, Australia(likely remote) X-ray crystallography has been the cornerstone of structural biology for half a century, and remains the technique of choice for atomic resolution understanding of macromolecules and for structure guided drug discovery. This intense course combines laboratory and computational instruction to train course participants in the major techniques used to determine three-dimensional structures. It is designed for scientists with a working knowledge of protein structure and function, but who are new to macromolecular crystallography or who wish to increase their in-depth knowledge of macromolecular crystallography. Topics to be covered include Basic diffraction theory Crystallization (proteins, nucleic acids, complexes and membrane proteins) Synchrotron X-ray sources and optics Data collection and processing Structure solution by experimental phasing methods (SAD, MAD, MIR, and others) and molecular replacement Electron density maps improvement Model building and refinement Structure validation Coordinate deposition Structure presentation If you are interested in applying for this course please let us know by submitting the Expression of Interest form via the course website as soon as possible. Please click this link to go to the Macromolecular Crystallography course website for further info. https://r20.rs6.net/tn.jsp?f=001eym31bmCvuxG3gZdQKD4XByq24-SM132UB2keWmTzFcYTJsNKVNY4eHzXSq4U43Qr4KZxVRbZZjZEneOcWJWRN45Ql8y0KKYUEMC3NmHp-IIUOZZSlg4TcGTnaLm3xETiv9uO2Q45sD9xUugNyAH-EXSEJqXiuwQ4ZHEIhbgNEMOuWNx3cjj-ijP7tkOLUiDLV1GVUInH-I=&c=f6-XRY5ZwGsmnf8lQOl7zXzDW0qRVcpgqB0oaHmDdl1pE2O99AwCcA==&ch=q7ShevqbNThKJM_fcxc76rhMcFKTjc0vPsYuk4J_SaEutikLx0acdg==

Cold Spring Harbor Laboratory - Meetings & Courses | 1 Bungtown Road, Cold Spring Harbor, NY 11724

-- Paul Adams Division Director, Molecular Biophysics & Integrated Bioimaging, LBL (http://biosciences.lbl.gov/divisions/mbib) Principal Investigator, Computational Crystallography Initiative, LBL (http://cci.lbl.gov) Vice President for Technology, the Joint BioEnergy Institute (http://www.jbei.org) Principal Investigator, ALS-ENABLE, Advanced Light Source (http://als-enable.lbl.gov) Division Deputy for Biosciences, Advanced Light Source (https://als.lbl.gov) Laboratory Research Manager, ENIGMA Science Focus Area (http://enigma.lbl.gov) Adjunct Professor, Department of Bioengineering, U.C. Berkeley (http://bioeng.berkeley.edu) Member of the Graduate Group in Comparative Biochemistry, U.C. Berkeley (http://compbiochem.berkeley.edu) Building 33, Room 250 Building 978, Room 4126 Building 977, Room 180C Tel: 1-510-486-4225 http://cci.lbl.gov/paul http://cci.lbl.gov/paul ORCID: 0000-0001-9333-8219 Lawrence Berkeley Laboratory 1 Cyclotron Road BLDG 33R0345 Berkeley, CA 94720, USA. Executive Assistant: Ashley Dawn [ [email protected] ][ 1-510-486-5455 ] --